PMID- 24722042
OWN - NLM
STAT- MEDLINE
DCOM- 20140508
LR  - 20161125
IS  - 1074-9357 (Print)
IS  - 1074-9357 (Linking)
VI  - 21 Suppl 1
DP  - 2014
TI  - Impact of BDNF -196 G>A and BDNF -270 C>T polymorphisms on stroke rehabilitation 
      outcome: sex and age differences.
PG  - S33-41
LID - 10.1310/tsr21S1-S33 [doi]
AB  - BACKGROUND: Genetic factors, including gene polymorphisms, are promising in 
      determining stroke rehabilitation outcome. Brain-derived neurotrophic factor 
      (BDNF) is one of the most attractive because of its role in neuroplasticity and 
      brain repair. OBJECTIVE: The aim of present study was to assess the role of BDNF 
      -196 Gnot greater-thanA (val66met) and -270 Cnot greater-thanT on clinical parameters and functional outcome in 
      patients with ischemic and hemorrhagic stroke. Additional analyses according to 
      sex and age (</=55 and not greater-than55 years) were performed. METHODS: Three hundred 
      thirty-eight patients (287 with ischemic and 51 with hemorrhagic stroke) were 
      evaluated in terms of neurological deficit (National Institute of Heath Stroke 
      Scale [NIHSS]), activities of daily living (Barthel Index [BI]), and everyday 
      functionality (Rankin score [RS]) before and after rehabilitation. BDNF 
      polymorphism genotyping was performed by polymerase chain reaction restriction 
      fragment length polymorphism analysis. RESULTS: In multivariative analysis, 
      unfavorable outcome of stroke rehabilitation (RS >/=2) was associated with 
      independent factors: ischemic stroke (odds ratio [OR], 2.59; 95% CI, 1.03-6.47), 
      female gender (OR, 2.80; 95% CI, 1.39-5.64), depression (OR, 4.24; 95% CI, 
      1.45-12.35), falls (OR, 2.61; 95% CI, 1.16-5.87), and BDNF -196 GG polymorphism 
      (OR, 2.18; 95% CI, 1.09-4.35). The differences of functional parameters measured 
      with BI and RS on admission and at discharge are apparent only for comparisons 
      between patients </=55 and not greater-than55 years old carrying BDNF -196 GA+AA genotypes but not 
      in those carrying -196 GG genotype; the differences were evident in women but not 
      in men. CONCLUSIONS: BDNF -196 Gnot greater-thanA polymorphism might affect functional outcome 
      of stroke rehabilitation, but this hypothesis needs further verification.
FAU - Mirowska-Guzel, Dagmara
AU  - Mirowska-Guzel D
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Warsaw, Poland 2nd Department of Neurology, Rehabilitation Ward, 
      Institute of Psychiatry and Neurology, Warsaw, Poland.
FAU - Gromadzka, Grazyna
AU  - Gromadzka G
AD  - 2nd Department of Neurology, Rehabilitation Ward, Institute of Psychiatry and 
      Neurology, Warsaw, Poland.
FAU - Mendel, Tadeusz
AU  - Mendel T
AD  - 2nd Department of Neurology, Rehabilitation Ward, Institute of Psychiatry and 
      Neurology, Warsaw, Poland.
FAU - Janus-Laszuk, Barbara
AU  - Janus-Laszuk B
AD  - 2nd Department of Neurology, Rehabilitation Ward, Institute of Psychiatry and 
      Neurology, Warsaw, Poland.
FAU - Dzierka, Justyna
AU  - Dzierka J
AD  - 2nd Department of Neurology, Rehabilitation Ward, Institute of Psychiatry and 
      Neurology, Warsaw, Poland.
FAU - Sarzynska-Dlugosz, Iwona
AU  - Sarzynska-Dlugosz I
AD  - 2nd Department of Neurology, Rehabilitation Ward, Institute of Psychiatry and 
      Neurology, Warsaw, Poland.
FAU - Czlonkowski, Andrzej
AU  - Czlonkowski A
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Warsaw, Poland.
FAU - Czlonkowska, Anna
AU  - Czlonkowska A
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Warsaw, Poland 2nd Department of Neurology, Rehabilitation Ward, 
      Institute of Psychiatry and Neurology, Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Top Stroke Rehabil
JT  - Topics in stroke rehabilitation
JID - 9439750
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging
MH  - Alleles
MH  - Brain Ischemia/complications/rehabilitation
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA/genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Intracranial Hemorrhages/complications/rehabilitation
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Polymorphism, Genetic/*genetics
MH  - Sex Characteristics
MH  - Stroke/classification/complications
MH  - *Stroke Rehabilitation
MH  - Treatment Outcome
OTO - NOTNLM
OT  - age
OT  - brain-derived neurotrophic factor (BDNF)
OT  - polymorphism
OT  - rehabilitation
OT  - stroke
EDAT- 2014/04/12 06:00
MHDA- 2014/05/09 06:00
CRDT- 2014/04/12 06:00
PHST- 2014/04/12 06:00 [entrez]
PHST- 2014/04/12 06:00 [pubmed]
PHST- 2014/05/09 06:00 [medline]
AID - N1533X20245113HL [pii]
AID - 10.1310/tsr21S1-S33 [doi]
PST - ppublish
SO  - Top Stroke Rehabil. 2014;21 Suppl 1:S33-41. doi: 10.1310/tsr21S1-S33.