PMID- 24722947
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20211021
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Linking)
VI  - 92
IP  - 5
DP  - 2014 May
TI  - CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4.
PG  - 433-9
LID - 10.1007/s00109-014-1123-8 [doi]
AB  - Chemokines were recognized originally for their ability to dictate the migration 
      and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also 
      known as stromal cell-derived factor-1) and its receptor CXCR4 are the first 
      chemokine and receptor that have been shown to be critical for developmental 
      processes, including homing and maintenance of hematopoietic stem cells (HSCs), 
      production of immune cells, homing of primordial germ cells (PGCs), 
      cardiogenesis, arterial vessel branching in some organs, and appropriate 
      assemblies of particular types of neurons. This review focuses on the 
      pathophysiological relevance of CXCL12-CXCR4 signaling in mammals.
FAU - Nagasawa, Takashi
AU  - Nagasawa T
AD  - Department of Immunobiology and Hematology, Institute for Frontier Medical 
      Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, 
      Japan, tnagasa@frontier.kyoto-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140411
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Animals
MH  - Chemokine CXCL12/analysis/*immunology/metabolism
MH  - Hematopoiesis
MH  - Humans
MH  - Immune System/cytology
MH  - Neoplasms/immunology/pathology
MH  - Neovascularization, Physiologic
MH  - Neurogenesis
MH  - Receptors, CXCR4/analysis/*immunology/metabolism
MH  - Signal Transduction
EDAT- 2014/04/12 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/04/12 06:00
PHST- 2013/07/29 00:00 [received]
PHST- 2013/12/27 00:00 [accepted]
PHST- 2013/12/24 00:00 [revised]
PHST- 2014/04/12 06:00 [entrez]
PHST- 2014/04/12 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s00109-014-1123-8 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2014 May;92(5):433-9. doi: 10.1007/s00109-014-1123-8. Epub 2014 
      Apr 11.