PMID- 2472307
OWN - NLM
STAT- MEDLINE
DCOM- 19890803
LR  - 20190903
IS  - 0721-832X (Print)
IS  - 0721-832X (Linking)
VI  - 227
IP  - 3
DP  - 1989
TI  - Experimental subretinal neovascularization in the rabbit.
PG  - 257-62
AB  - Subretinal neovascularization (SRN) in the rabbit was induced by subretinal 
      injection of vitreous without rupture of Bruch's membrane. Eight of 26 eyes 
      developed SRN. The incidence of SRN rose from 33% to 57% in a period of 4-40 
      weeks. Because of the absence of any fluorescein angiographic indication of SRN, 
      these occult new vessels were identified by light and transmission electron 
      microscopy. Histological examination showed that these newly formed vessels are 
      composed of continuous capillaries with the morphologic characteristics of 
      choriocapillaris, including diaphragmed fenestrations, basement membranes, and 
      junctional complexes. The new vessels originated from the choriocapillaris and 
      penetrated through Bruch's membrane into the subretinal space, where they were 
      associated with the degenerated sensory retina and proliferating glial and/or RPE 
      cells. This experiment provides a model of SRN without breaks in Bruch's 
      membrane.
FAU - Zhu, Z R
AU  - Zhu ZR
AD  - Department of Ophthalmology, University of Southern California, Los Angeles 
      90033.
FAU - Goodnight, R
AU  - Goodnight R
FAU - Sorgente, N
AU  - Sorgente N
FAU - Ogden, T E
AU  - Ogden TE
FAU - Ryan, S J
AU  - Ryan SJ
LA  - eng
GR  - EY01545/EY/NEI NIH HHS/United States
GR  - EY03040/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Animals
MH  - Fundus Oculi
MH  - Injections
MH  - Models, Biological
MH  - Neovascularization, Pathologic/*pathology
MH  - Pigment Epithelium of Eye/pathology
MH  - Rabbits
MH  - Retina/*blood supply/ultrastructure
MH  - Time Factors
MH  - Vitreous Body
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1007/BF02172759 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 1989;227(3):257-62. doi: 10.1007/BF02172759.