PMID- 24723311
OWN - NLM
STAT- MEDLINE
DCOM- 20150220
LR  - 20140705
IS  - 1099-1557 (Electronic)
IS  - 1053-8569 (Linking)
VI  - 23
IP  - 7
DP  - 2014 Jul
TI  - Indirect evidence for proton pump inhibitor failure in patients taking them 
      independent of meals.
PG  - 768-72
LID - 10.1002/pds.3620 [doi]
AB  - PURPOSE: We investigated the association between conditions of proton pump 
      inhibitor (PPI) treatment failure and food intake in an elderly ambulatory 
      population. METHODS: Our data originate from a large population-based cohort 
      study. During a home visit done by a trained study physician, patients were asked 
      for each medication to state whether it was taken in relation to a meal (before, 
      concurrently with, and after) or independent of a meal. This information was 
      analyzed for all patients taking a PPI daily and correlated to markers of PPI 
      failure. RESULTS: Out of 2717 patients participating in a home visit and taking 
      at least one medication, 383 took a PPI daily (14.1%). A PPI intake independent 
      of meals was defined as incorrect and was observed in 64 patients, whereas 319 
      patients took their PPI in relation to a meal, which was defined as the correct 
      intake. Treatment failure was observed in 10 out of 64 (15.6%) PPI users with 
      incorrect intake and in 18 out of 319 (5.6%) PPI users with correct intake. The 
      risk of treatment failure was threefold higher in patients taking their PPI 
      independent of meals (OR 3.35; 95%CI 1.44-7.76). CONCLUSION: The higher risk for 
      PPI failure in patients taking PPIs independent of meals suggests that 
      synchronized PPI administration with meals is indeed essential, and better 
      counseling of patients is needed.
CI  - Copyright (c) 2014 John Wiley & Sons, Ltd.
FAU - Freigofas, Julia
AU  - Freigofas J
AD  - Department of Clinical Pharmacology and Pharmacoepidemiology, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Haefeli, Walter E
AU  - Haefeli WE
FAU - Schottker, Ben
AU  - Schottker B
FAU - Brenner, Hermann
AU  - Brenner H
FAU - Quinzler, Renate
AU  - Quinzler R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140410
PL  - England
TA  - Pharmacoepidemiol Drug Saf
JT  - Pharmacoepidemiology and drug safety
JID - 9208369
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Food-Drug Interactions
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Education as Topic/*methods
MH  - Proton Pump Inhibitors/administration & dosage/*therapeutic use
MH  - Treatment Failure
OTO - NOTNLM
OT  - food intake
OT  - pharmacoepidemiology
OT  - proton pump inhibitor
OT  - treatment failure
EDAT- 2014/04/12 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/04/12 06:00
PHST- 2013/10/15 00:00 [received]
PHST- 2014/01/09 00:00 [revised]
PHST- 2014/03/10 00:00 [accepted]
PHST- 2014/04/12 06:00 [entrez]
PHST- 2014/04/12 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 10.1002/pds.3620 [doi]
PST - ppublish
SO  - Pharmacoepidemiol Drug Saf. 2014 Jul;23(7):768-72. doi: 10.1002/pds.3620. Epub 
      2014 Apr 10.