PMID- 24723651
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20140805
IS  - 1952-4013 (Electronic)
IS  - 1167-1122 (Linking)
VI  - 24
IP  - 3
DP  - 2014 May-Jun
TI  - Recurrent angioedema: diagnosis strategy and biological aspects.
PG  - 293-6
LID - 10.1684/ejd.2014.2276 [doi]
AB  - The aetiologies of recurrent angioedema (AE) comprise the frequent histaminergic 
      AE and the rare bradykinin-mediated AE. Diagnosis must be done carefully because 
      they do not have the same treatment. Diagnosis strategy is clinical. The most 
      specific symptoms for bradykinin AE are: isolated AE without wheals, long 
      duration of the attack, abdominal localisation. The unique useful biological 
      tests for the diagnosis of bradykinin AE are C1Inh exploration which is altered 
      in hereditary AE (HAE) types I and II. No other biological test is useful in 
      clinical practice at present. In case of suspicion of bradykinin AE with normal 
      C1Inh, physicians must think of drug-induced AE. Hereditary AE with normal C1Inh 
      may be associated with a mutation on gene F12 in 20% of cases. For 80% of 
      patients without mutation, the diagnosis must be done very carefully.
FAU - Bouillet, Laurence
AU  - Bouillet L
AD  - National Reference Centre for Angioedema (CREAK), Internal medicine department, 
      Grenoble University Hospital, BP 217 38043 Grenoble cedex 09 France, Unite Inserm 
      1036, CEA, Universite de medecine Joseph-Fourier, Grenoble, France.
FAU - Boccon-Gibod, Isabelle
AU  - Boccon-Gibod I
AD  - National Reference Centre for Angioedema (CREAK), Internal medicine department, 
      Grenoble University Hospital, BP 217 38043 Grenoble cedex 09 France.
FAU - Berard, Frederic
AU  - Berard F
AD  - Universite Lyon1, Immunology and Allergy Clinic, Inserm U1111-CIRI, CHU Lyon Sud, 
      69495 Pierre-Benite, France.
FAU - Nicolas, Jean-Francois
AU  - Nicolas JF
AD  - Universite Lyon1, Immunology and Allergy Clinic, Inserm U1111-CIRI, CHU Lyon Sud, 
      69495 Pierre-Benite, France.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
RN  - 820484N8I3 (Histamine)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Angioedema/*diagnosis/etiology
MH  - Bradykinin/physiology
MH  - Histamine/physiology
MH  - Humans
MH  - Recurrence
OTO - NOTNLM
OT  - C1Inh
OT  - angioedema
OT  - bradykinin
OT  - diagnosis
OT  - histamine
OT  - urticaria
EDAT- 2014/04/12 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/04/12 06:00
PHST- 2014/04/12 06:00 [entrez]
PHST- 2014/04/12 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - ejd.2014.2276 [pii]
AID - 10.1684/ejd.2014.2276 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2014 May-Jun;24(3):293-6. doi: 10.1684/ejd.2014.2276.