PMID- 24723739
OWN - NLM
STAT- MEDLINE
DCOM- 20150119
LR  - 20211021
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2014
DP  - 2014
TI  - Impact of serum biomarkers and clinical factors on intensive care unit mortality 
      and 6-month outcome in relatively healthy patients with severe pneumonia and 
      acute respiratory distress syndrome.
PG  - 804654
LID - 10.1155/2014/804654 [doi]
LID - 804654
AB  - OBJECTIVES: This study aimed to identify the independent biomarkers and clinical 
      factors that could predict ICU mortality and 6-month outcomes in relatively 
      healthy patients with severe pneumonia and acute respiratory distress syndrome 
      (ARDS). PATIENTS AND METHODS: We prospectively enrolled patients with severe 
      pneumonia-related ARDS that required mechanical ventilation. Patients were 
      excluded if they were unable to take care of themselves. Several biomarkers and 
      clinical factors were evaluated prospectively on day 1 and day 3 after ICU 
      admission. All biomarkers and clinical factors were collected for analysis. 
      RESULTS: 56 patients were enrolled in this study. We determined that the initial 
      appropriate antibiotics use was an independent clinical factor and day 1 
      high-mobility group protein B1 (HMGB1) concentration was an independent biomarker 
      for ICU mortality. Interestingly, we also found that a low day 1 albumin level 
      was an independent biomarker for predicting patient life dependence 6 months 
      after a pneumonia event. CONCLUSION: Patients with severe pneumonia and ARDS 
      requiring mechanical ventilation experience high rates of ICU mortality or 
      disability, even if they were quite healthy before. Initial appropriate 
      antibiotics use and day 1 level of HMGB1 were independent factors for predicting 
      ICU mortality. Day 1 albumin level was predictive of 6-month patient life 
      dependence.
FAU - Tseng, Chia-Cheng
AU  - Tseng CC
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 
      College of Medicine, Kaohsiung 83301, Taiwan ; Department of Respiratory Care, 
      Chang Gung University of Science and Technology, Chiayi 813, Taiwan.
FAU - Fang, Wen-Feng
AU  - Fang WF
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 
      College of Medicine, Kaohsiung 83301, Taiwan ; Department of Respiratory Care, 
      Chang Gung University of Science and Technology, Chiayi 813, Taiwan ; Department 
      of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung 83301, Taiwan.
FAU - Leung, Sum-Yee
AU  - Leung SY
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 
      College of Medicine, Kaohsiung 83301, Taiwan ; Department of Respiratory Care, 
      Chang Gung University of Science and Technology, Chiayi 813, Taiwan.
FAU - Chen, Hung-Chen
AU  - Chen HC
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 
      College of Medicine, Kaohsiung 83301, Taiwan.
FAU - Chang, Ya-Chun
AU  - Chang YC
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 
      College of Medicine, Kaohsiung 83301, Taiwan.
FAU - Wang, Chin-Chou
AU  - Wang CC
AUID- ORCID: 0000-0003-2932-751X
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 
      College of Medicine, Kaohsiung 83301, Taiwan ; Department of Respiratory Care, 
      Chang Gung University of Science and Technology, Chiayi 813, Taiwan ; Department 
      of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung 83301, Taiwan.
FAU - Chang, Huang-Chih
AU  - Chang HC
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 
      College of Medicine, Kaohsiung 83301, Taiwan ; Department of Respiratory Care, 
      Chang Gung University of Science and Technology, Chiayi 813, Taiwan.
FAU - Lin, Meng-Chih
AU  - Lin MC
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 
      College of Medicine, Kaohsiung 83301, Taiwan ; Department of Respiratory Care, 
      Chang Gung University of Science and Technology, Chiayi 813, Taiwan ; Department 
      of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung 83301, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140303
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 0 (HMGB1 Protein)
RN  - 0 (HMGB1 protein, human)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Critical Care
MH  - Female
MH  - HMGB1 Protein/*blood
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Pneumonia/*blood/mortality
MH  - Prospective Studies
MH  - Respiratory Distress Syndrome/*blood/mortality
MH  - Treatment Outcome
PMC - PMC3958786
EDAT- 2014/04/12 06:00
MHDA- 2015/01/20 06:00
PMCR- 2014/03/03
CRDT- 2014/04/12 06:00
PHST- 2013/12/30 00:00 [received]
PHST- 2014/01/29 00:00 [accepted]
PHST- 2014/04/12 06:00 [entrez]
PHST- 2014/04/12 06:00 [pubmed]
PHST- 2015/01/20 06:00 [medline]
PHST- 2014/03/03 00:00 [pmc-release]
AID - 10.1155/2014/804654 [doi]
PST - ppublish
SO  - Dis Markers. 2014;2014:804654. doi: 10.1155/2014/804654. Epub 2014 Mar 3.