PMID- 24724052
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 4
DP  - 2014
TI  - Culture models to define key mediators of cancer matrix remodeling.
PG  - 57
LID - 10.3389/fonc.2014.00057 [doi]
LID - 57
AB  - High grade serous epithelial ovarian cancer (HG-SOC) is one of the most 
      devastating gynecological cancers affecting women worldwide, with a poor survival 
      rate despite clinical treatment advances. HG-SOC commonly metastasizes within the 
      peritoneal cavity, primarily to the mesothelial cells of the omentum, which 
      regulate an extracellular matrix rich in collagens type I, III, and IV along with 
      laminin, vitronectin, and fibronectin. Cancer cells depend on their ability to 
      penetrate and invade secondary tissue sites to spread, however a detailed 
      understanding of the molecular mechanisms underlying these processes remain 
      largely unknown. Given the high metastatic potential of HG-SOC and the associated 
      poor clinical outcome, it is extremely important to identify the pathways and the 
      components of which that are responsible for the progression of this disease. In 
      vitro methods of recapitulating human disease processes are the critical first 
      step in such investigations. In this context, establishment of an in vitro 
      "tumor-like" micro-environment, such as 3D culture, to study early disease and 
      metastasis of human HG-SOC is an important and highly insightful method. In 
      recent years, many such methods have been established to investigate the adhesion 
      and invasion of human ovarian cancer cell lines. The aim of this review is to 
      summarize recent developments in ovarian cancer culture systems and their use to 
      investigate clinically relevant findings concerning the key players in driving 
      human HG-SOC.
FAU - Fuller, Emily Suzanne
AU  - Fuller ES
AD  - Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical 
      Research, Royal North Shore Hospital, University of Sydney , St. Leonards, NSW , 
      Australia.
FAU - Howell, Viive Maarika
AU  - Howell VM
AD  - Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical 
      Research, Royal North Shore Hospital, University of Sydney , St. Leonards, NSW , 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140325
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC3971193
OTO - NOTNLM
OT  - 3D
OT  - culture models
OT  - high grade serous epithelial ovarian cancer
OT  - metastasis
OT  - synthetic scaffolds
EDAT- 2014/04/12 06:00
MHDA- 2014/04/12 06:01
PMCR- 2014/01/01
CRDT- 2014/04/12 06:00
PHST- 2014/01/21 00:00 [received]
PHST- 2014/03/11 00:00 [accepted]
PHST- 2014/04/12 06:00 [entrez]
PHST- 2014/04/12 06:00 [pubmed]
PHST- 2014/04/12 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2014.00057 [doi]
PST - epublish
SO  - Front Oncol. 2014 Mar 25;4:57. doi: 10.3389/fonc.2014.00057. eCollection 2014.