PMID- 24724906
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20140728
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 84
IP  - 2
DP  - 2014 Aug
TI  - The heterogeneous HLA genetic composition of the Brazilian population and its 
      relevance to the optimization of hematopoietic stem cell donor recruitment.
PG  - 187-97
LID - 10.1111/tan.12352 [doi]
AB  - The aim of this study was to investigate the human leukocyte antigen (HLA) 
      molecular variation across the Brazilian population in order to determine 
      possible regional differences, which would be highly relevant to optimizing donor 
      recruitment strategies in hematopoietic stem cell transplantation (HSCT) and 
      understanding the population genetic background of this heterogeneous country. 
      HLA data of 551 HSCT donors from five Brazilian regions were characterized by 
      high-resolution DNA alleles at the HLA-A, -B, -C, -DRB1 and -DQB1 loci and 
      compared with other populations in Brazil and worldwide populations. Allele and 
      haplotype frequencies were estimated. The analysis was performed to assess 
      Hardy-Weinberg equilibrium (HWE) and linkage disequilibrium (LD) among different 
      loci in each recruitment center. Genetic variation was explored through genetic 
      distance analyzed by using a new algorithm based on linear algebra, taking into 
      account geographic regions of Brazil. The results indicated a heterogeneous 
      genetic composition of the Brazilian population, such that HLA allele and 
      haplotype frequencies exhibit different distributions among Brazilian regions, 
      which has important implications for donor matching. In addition, a pronounced 
      differentiation was observed by the absence of clustering of the regional 
      populations in the reduced-dimension space. These data may be useful for 
      increasing donor recruitment with more genetic representativeness in the 
      Brazilian Volunteer Bone Marrow Donors Registry (REDOME).
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Fabreti-Oliveira, R A
AU  - Fabreti-Oliveira RA
AD  - Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, 
      Belo Horizonte, MG, Brazil; Departamento da Ciencia da Computacao, Universidade 
      Federal de Minas Gerais, Belo Horizonte, MG, Brazil; IMUNOLAB - Laboratorio de 
      Histocompatibilidade, Imunogenetica e Imunologia de Transplantes, Belo Horizonte, 
      MG, Brazil.
FAU - Nascimento, E
AU  - Nascimento E
FAU - Fonseca, C G
AU  - Fonseca CG
FAU - Santos, M A
AU  - Santos MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140412
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Brazil
MH  - *Donor Selection
MH  - Gene Frequency/genetics
MH  - Genetic Loci/genetics
MH  - Genetic Variation
MH  - *Genetics, Population
MH  - Geography
MH  - HLA Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Middle Aged
MH  - Phylogeny
MH  - *Tissue Donors
MH  - Young Adult
OTO - NOTNLM
OT  - Brazilian population
OT  - computational biology
OT  - genetic distances
OT  - human leukocyte antigen allele and haplotype frequencies
OT  - linear algebra
OT  - sequence-based typing
EDAT- 2014/04/15 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/04/15 06:00
PHST- 2013/08/26 00:00 [received]
PHST- 2014/02/20 00:00 [revised]
PHST- 2014/03/17 00:00 [accepted]
PHST- 2014/04/15 06:00 [entrez]
PHST- 2014/04/15 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1111/tan.12352 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Aug;84(2):187-97. doi: 10.1111/tan.12352. Epub 2014 Apr 12.