PMID- 24725415 OWN - NLM STAT- MEDLINE DCOM- 20140717 LR - 20210103 IS - 1097-4172 (Electronic) IS - 0092-8674 (Linking) VI - 157 IP - 2 DP - 2014 Apr 10 TI - SnapShot: cancer vaccines. PG - 516-516.e1 LID - S0092-8674(14)00420-6 [pii] LID - 10.1016/j.cell.2014.03.044 [doi] AB - This SnapShot illustrates the main concepts and underlying biology of therapeutic vaccination in cancer. Dendritic cells (DCs) are an essential component of vaccination through their capacity to capture, process, and present antigens to T cells. We have come a long way in our understanding of what is needed to elicit therapeutic immunity when cancer escapes the natural barrier of protective immunity. This progress enables the development of novel vaccines. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Palucka, Karolina AU - Palucka K AD - Ralph M. Steinman Center for Cancer Vaccines, Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA. FAU - Banchereau, Jacques AU - Banchereau J AD - The Jackson Laboratory, Farmington, CT 06030, USA. LA - eng PT - Journal Article PL - United States TA - Cell JT - Cell JID - 0413066 RN - 0 (Cancer Vaccines) SB - IM MH - Animals MH - Antigen Presentation MH - Cancer Vaccines/*immunology MH - Dendritic Cells/*immunology MH - Humans MH - Neoplasms/*immunology/therapy EDAT- 2014/04/15 06:00 MHDA- 2014/07/18 06:00 CRDT- 2014/04/15 06:00 PHST- 2014/04/15 06:00 [entrez] PHST- 2014/04/15 06:00 [pubmed] PHST- 2014/07/18 06:00 [medline] AID - S0092-8674(14)00420-6 [pii] AID - 10.1016/j.cell.2014.03.044 [doi] PST - ppublish SO - Cell. 2014 Apr 10;157(2):516-516.e1. doi: 10.1016/j.cell.2014.03.044.