PMID- 24725497 OWN - NLM STAT- MEDLINE DCOM- 20170413 LR - 20170413 IS - 1752-699X (Electronic) IS - 1752-6981 (Linking) VI - 9 IP - 4 DP - 2015 Oct TI - A new pattern of pulmonary graft vs host disease in a hematopoietic stem cell transplant patient. PG - 399-402 LID - 10.1111/crj.12136 [doi] AB - BACKGROUND: The primary pulmonary manifestation of chronic graft vs host disease (GvHD) is the development of bronchiolitis obliterans. Other pulmonary manifestations of chronic GvHD that have been reported include diffuse alveolar damage, lymphocytic interstitial pneumonia, bronchiolitis organising pneumonia and lymphocytic bronchiolitis/bronchitis. CASE PRESENTATION: We report an unusual case of a 34-year-old patient with acute myeloid leukaemia, status post-allogenic hematopoietic stem cell transplantation who subsequently developed GvHD with skin involvement. He presented to our hospital with new onset respiratory failure and on subsequent surgical lung biopsy was found to have non-specific interstitial pneumonia (NSIP). CONCLUSION: This is the third case of a patient with biopsy-proven GvHD who had NSIP pattern on surgical lung biopsy. We believe this may represent a rare manifestation of pulmonary GvHD. CI - (c) 2014 John Wiley & Sons Ltd. FAU - Wahla, Ali S AU - Wahla AS AD - Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. FAU - Khan, Irtaza I AU - Khan II AD - Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. FAU - Loya, Asif AU - Loya A AD - Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan. FAU - Chin, Robert Jr AU - Chin R Jr AD - Pulmonary and Critical Care Division, Wake Forest University Baptist Medical Center, Winston Salem, NC, USA. LA - eng PT - Case Reports PT - Journal Article DEP - 20140521 PL - England TA - Clin Respir J JT - The clinical respiratory journal JID - 101315570 SB - IM MH - Adult MH - Biopsy MH - Graft vs Host Disease/*diagnosis/etiology MH - Hematopoietic Stem Cell Transplantation/*adverse effects MH - Humans MH - Leukemia, Myeloid, Acute/*therapy MH - Lung/pathology MH - Lung Diseases, Interstitial/*etiology/pathology MH - Male OTO - NOTNLM OT - graft vs host disease OT - hematopoietic stem cell transplant OT - non-specific interstitial pneumonia OT - respiratory failure EDAT- 2014/04/15 06:00 MHDA- 2017/04/14 06:00 CRDT- 2014/04/15 06:00 PHST- 2013/11/15 00:00 [received] PHST- 2014/04/04 00:00 [accepted] PHST- 2014/04/15 06:00 [entrez] PHST- 2014/04/15 06:00 [pubmed] PHST- 2017/04/14 06:00 [medline] AID - 10.1111/crj.12136 [doi] PST - ppublish SO - Clin Respir J. 2015 Oct;9(4):399-402. doi: 10.1111/crj.12136. Epub 2014 May 21.