PMID- 24726197
OWN - NLM
STAT- MEDLINE
DCOM- 20140728
LR  - 20211021
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Print)
IS  - 1081-1206 (Linking)
VI  - 112
IP  - 6
DP  - 2014 Jun
TI  - Relationship between urine dichlorophenol levels and asthma morbidity.
PG  - 511-518.e1
LID - S1081-1206(14)00195-1 [pii]
LID - 10.1016/j.anai.2014.03.011 [doi]
AB  - BACKGROUND: Chlorinated phenols are associated with atopic conditions, but it is 
      not known whether they are associated with wheeze or asthma and whether atopy is 
      involved in these associations. OBJECTIVES: To test the association between urine 
      levels of 2 dichlorophenols (2,4- and 2,5-dichlorophenols) and asthma morbidity 
      in atopic and nonatopic wheezers and between total serum immunoglobulin E (IgE) 
      levels. METHODS: Data from a sample of 2,125 participants at least 6 years old 
      from the US National Health and Nutrition Examination Survey 2005 to 2006 were 
      analyzed. Asthma morbidity data were available for those participants who 
      reported wheezing in the past year ("wheezers"; n = 250). This subsample was 
      categorized as atopic or nonatopic. RESULTS: Atopic wheezers with higher 
      2,5-dichlorophenol levels were more frequently diagnosed with asthma by a 
      physician (odds ratio [OR] 4.7 for highest vs lowest tertile, P < .001), required 
      more prescriptions for asthma medications (OR 2.2, P = .046), and reported more 
      exercise-induced wheezing (OR 5.8, P = .045) than atopic wheezers with low 
      dichlorophenol levels. Atopic wheezers with higher 2,5- or 2,4-dichloropheonol 
      levels also were more likely to miss work or school because of wheezing (OR 10.0, 
      P < .001; OR 11.4, P < .01, respectively). In contrast, in nonatopic wheezers, 
      there were no significant associations between dichlorophenol levels and asthma 
      morbidity measurements. The 2 dichlorophenol metabolites were positively 
      associated with increased serum IgE levels in the larger study sample. 
      CONCLUSION: These findings indicate that in patients with atopy and a history of 
      wheezing, asthma morbidity is associated with high urinary dichlorophenol levels. 
      Increased urine dichlorophenol levels are associated with higher total serum IgE.
CI  - Copyright (c) 2014 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Jerschow, Elina
AU  - Jerschow E
AD  - Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical 
      Center, Bronx, New York. Electronic address: elina.jerschow@einstein.yu.edu.
FAU - Parikh, Purvi
AU  - Parikh P
AD  - Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical 
      Center, Bronx, New York.
FAU - McGinn, Aileen P
AU  - McGinn AP
AD  - Department of Epidemiology and Population Health, Albert Einstein College of 
      Medicine, Bronx, New York.
FAU - de Vos, Gabriele
AU  - de Vos G
AD  - Department of Medicine, Albert Einstein College of Medicine/Jacobi Medical 
      Center, Bronx, New York.
FAU - Jariwala, Sunit
AU  - Jariwala S
AD  - Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical 
      Center, Bronx, New York.
FAU - Hudes, Golda
AU  - Hudes G
AD  - Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical 
      Center, Bronx, New York.
FAU - Rosenstreich, David
AU  - Rosenstreich D
AD  - Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical 
      Center, Bronx, New York.
LA  - eng
GR  - KL2 RR025749/RR/NCRR NIH HHS/United States
GR  - KL2 TR001071/TR/NCATS NIH HHS/United States
GR  - TL1 RR025748/RR/NCRR NIH HHS/United States
GR  - UL1 RR025750/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140413
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Chlorophenols)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3B11G9AKBA (2,5-dichlorophenol)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Adult
MH  - Asthma/drug therapy/*urine
MH  - Chlorophenols/*urine
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Respiratory Sounds/drug effects
MH  - Surveys and Questionnaires
PMC - PMC4058323
MID - NIHMS580055
EDAT- 2014/04/15 06:00
MHDA- 2014/07/30 06:00
PMCR- 2015/06/01
CRDT- 2014/04/15 06:00
PHST- 2014/01/04 00:00 [received]
PHST- 2014/03/19 00:00 [revised]
PHST- 2014/03/21 00:00 [accepted]
PHST- 2014/04/15 06:00 [entrez]
PHST- 2014/04/15 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - S1081-1206(14)00195-1 [pii]
AID - 10.1016/j.anai.2014.03.011 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2014 Jun;112(6):511-518.e1. doi: 
      10.1016/j.anai.2014.03.011. Epub 2014 Apr 13.