PMID- 24726582
OWN - NLM
STAT- MEDLINE
DCOM- 20151009
LR  - 20220409
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 24
IP  - 12
DP  - 2014 Dec
TI  - Brain imaging in type 2 diabetes.
PG  - 1967-81
LID - S0924-977X(14)00081-9 [pii]
LID - 10.1016/j.euroneuro.2014.01.023 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction and 
      dementia. Brain imaging may provide important clues about underlying processes. 
      This review focuses on the relationship between T2DM and brain abnormalities 
      assessed with different imaging techniques: both structural and functional 
      magnetic resonance imaging (MRI), including diffusion tensor imaging and magnetic 
      resonance spectroscopy, as well as positron emission tomography and single-photon 
      emission computed tomography. Compared to people without diabetes, people with 
      T2DM show slightly more global brain atrophy, which increases gradually over time 
      compared with normal aging. Moreover, vascular lesions are seen more often, 
      particularly lacunar infarcts. The association between T2DM and white matter 
      hyperintensities and microbleeds is less clear. T2DM has been related to 
      diminished cerebral blood flow and cerebrovascular reactivity, particularly in 
      more advanced disease. Diffusion tensor imaging is a promising technique with 
      respect to subtle white matter involvement. Thus, brain imaging studies show that 
      T2DM is associated with both degenerative and vascular brain damage, which 
      develops slowly over the course of many years. The challenge for future studies 
      will be to further unravel the etiology of brain damage in T2DM, and to identify 
      subgroups of patients that will develop distinct progressive brain damage and 
      cognitive decline.
CI  - Copyright (c) 2014 Elsevier B.V. and ECNP. All rights reserved.
FAU - Brundel, Manon
AU  - Brundel M
AD  - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, The Netherlands. Electronic address: M.Brundel-2@umcutrecht.nl.
FAU - Kappelle, L Jaap
AU  - Kappelle LJ
AD  - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, The Netherlands.
FAU - Biessels, Geert Jan
AU  - Biessels GJ
AD  - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140315
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
SB  - IM
MH  - Atrophy/pathology
MH  - Brain/*pathology
MH  - Cerebrovascular Circulation/physiology
MH  - Cerebrovascular Disorders/complications/*pathology
MH  - Diabetes Mellitus, Type 2/complications/*pathology/physiopathology
MH  - Diffusion Tensor Imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - *Neuroimaging
MH  - Tomography, Emission-Computed, Single-Photon
OTO - NOTNLM
OT  - Brain atrophy
OT  - Brain imaging
OT  - Cerebral blood flow
OT  - Diffusion tensor imaging
OT  - Magnetic resonance imaging
OT  - Type 2 diabetes
EDAT- 2014/04/15 06:00
MHDA- 2015/10/10 06:00
CRDT- 2014/04/15 06:00
PHST- 2013/12/16 00:00 [received]
PHST- 2014/01/23 00:00 [accepted]
PHST- 2014/04/15 06:00 [entrez]
PHST- 2014/04/15 06:00 [pubmed]
PHST- 2015/10/10 06:00 [medline]
AID - S0924-977X(14)00081-9 [pii]
AID - 10.1016/j.euroneuro.2014.01.023 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2014 Dec;24(12):1967-81. doi: 
      10.1016/j.euroneuro.2014.01.023. Epub 2014 Mar 15.