PMID- 24726984
OWN - NLM
STAT- MEDLINE
DCOM- 20150113
LR  - 20220408
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 270
DP  - 2014 Jun 13
TI  - Caffeine triggers behavioral and neurochemical alterations in adolescent rats.
PG  - 27-39
LID - S0306-4522(14)00291-7 [pii]
LID - 10.1016/j.neuroscience.2014.04.003 [doi]
AB  - Caffeine is the psychostimulant most consumed worldwide but concerns arise about 
      the growing intake of caffeine-containing drinks by adolescents since the effects 
      of caffeine on cognitive functions and neurochemical aspects of late brain 
      maturation during adolescence are poorly known. We now studied the behavioral 
      impact in adolescent male rats of regular caffeine intake at low (0.1mg/mL), 
      moderate (0.3mg/mL) and moderate/high (1.0mg/mL) doses only during their active 
      period (from 7:00 P.M. to 7:00 A.M.). All tested doses of caffeine were devoid of 
      effects on locomotor activity, but triggered anxiogenic effects. Caffeine (0.3 
      and 1mg/mL) improved the performance in the object recognition task, but the 
      higher dose of caffeine (1.0mg/mL) decreased the habituation to an open-field 
      arena, suggesting impaired non-associative memory. All tested doses of caffeine 
      decreased the density of glial fibrillary acidic protein and 
      synaptosomal-associated protein-25, but failed to modify neuron-specific nuclear 
      protein immunoreactivity in the hippocampus and cerebral cortex. Caffeine 
      (0.3-1mg/mL) increased the density of brain-derived neurotrophic factor (BDNF) 
      and proBDNF density as well as adenosine A1 receptor density in the hippocampus, 
      whereas the higher dose of caffeine (1mg/mL) increased the density of proBDNF and 
      BDNF and decreased A1 receptor density in the cerebral cortex. These findings 
      document an impact of caffeine consumption in adolescent rats with a dual impact 
      on anxiety and recognition memory, associated with changes in BDNF levels and 
      decreases of astrocytic and nerve terminal markers without overt neuronal damage 
      in hippocampal and cortical regions.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Ardais, A P
AU  - Ardais AP
AD  - Laboratorio de Estudos sobre o Sistema Purinergico, Universidade Federal Rio 
      Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de 
      Bioquimica, 90035-003 Porto Alegre/RS, Brazil.
FAU - Borges, M F
AU  - Borges MF
AD  - Laboratorio de Estudos sobre o Sistema Purinergico, Universidade Federal Rio 
      Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de 
      Bioquimica, 90035-003 Porto Alegre/RS, Brazil.
FAU - Rocha, A S
AU  - Rocha AS
AD  - Laboratorio de Estudos sobre o Sistema Purinergico, Universidade Federal Rio 
      Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de 
      Bioquimica, 90035-003 Porto Alegre/RS, Brazil.
FAU - Sallaberry, C
AU  - Sallaberry C
AD  - Laboratorio de Estudos sobre o Sistema Purinergico, Universidade Federal Rio 
      Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de 
      Bioquimica, 90035-003 Porto Alegre/RS, Brazil.
FAU - Cunha, R A
AU  - Cunha RA
AD  - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 
      Coimbra, Portugal; Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, 
      Portugal.
FAU - Porciuncula, L O
AU  - Porciuncula LO
AD  - Laboratorio de Estudos sobre o Sistema Purinergico, Universidade Federal Rio 
      Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de 
      Bioquimica, 90035-003 Porto Alegre/RS, Brazil. Electronic address: 
      loporciuncula@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140413
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Receptor, Adenosine A1)
RN  - 0 (Snap25 protein, rat)
RN  - 0 (Synaptosomal-Associated Protein 25)
RN  - 3G6A5W338E (Caffeine)
SB  - IM
MH  - Animals
MH  - Anxiety/*chemically induced/physiopathology
MH  - Brain/*drug effects/growth & development/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Caffeine/*pharmacology
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cerebral Cortex/drug effects/growth & development/physiology
MH  - Dose-Response Relationship, Drug
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/drug effects/growth & development/physiology
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Motor Activity/drug effects/physiology
MH  - Neurons/drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Adenosine A1/metabolism
MH  - Recognition, Psychology/*drug effects/physiology
MH  - Synaptosomal-Associated Protein 25/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - adenosine
OT  - anxiety
OT  - caffeine
OT  - memory
OT  - psychostimulants
EDAT- 2014/04/15 06:00
MHDA- 2015/01/15 06:00
CRDT- 2014/04/15 06:00
PHST- 2014/02/09 00:00 [received]
PHST- 2014/03/31 00:00 [revised]
PHST- 2014/04/01 00:00 [accepted]
PHST- 2014/04/15 06:00 [entrez]
PHST- 2014/04/15 06:00 [pubmed]
PHST- 2015/01/15 06:00 [medline]
AID - S0306-4522(14)00291-7 [pii]
AID - 10.1016/j.neuroscience.2014.04.003 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Jun 13;270:27-39. doi: 10.1016/j.neuroscience.2014.04.003. 
      Epub 2014 Apr 13.