PMID- 24728472
OWN - NLM
STAT- MEDLINE
DCOM- 20150602
LR  - 20211021
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Print)
IS  - 0931-041X (Linking)
VI  - 29
IP  - 10
DP  - 2014 Oct
TI  - Growth in children with chronic kidney disease: a report from the Chronic Kidney 
      Disease in Children Study.
PG  - 1987-95
LID - 10.1007/s00467-014-2812-9 [doi]
AB  - BACKGROUND: Growth failure is common among children with chronic kidney disease 
      (CKD). We examined the relationship of growth parameters with glomerular 
      filtration rate (GFR), CKD diagnosis, sex and laboratory results in children with 
      CKD. METHODS: Baseline data from 799 children (median age 11.0 years, median GFR 
      49.9 mL/min/1.73 m(2)) participating in the Chronic Kidney Disease in Children 
      Study were examined. Growth was quantified by age-sex-specific height, weight, 
      body mass index (BMI-age), and height-age-sex-specific BMI (BMI-height-age) 
      standard deviation scores (SDS). RESULTS: Median height and weight SDS were -0.55 
      [interquartile range (IQR) -1.35 to 0.19] and 0.03 (IQR -0.82 to 0.97), 
      respectively. Girls with non-glomerular CKD were the shortest (median height SDS 
      -0.83; IQR -1.62 to -0.02). Compared to those with a serum bicarbonate (CO2) 
      level of >/= 22 mEq/L, children with CO2 of <18 mEq/L had a height SDS that was on 
      average 0.67 lower [95 % confidence interval (CI) -0.31 to -1.03]. Only 23 % of 
      children with a height SDS of </=-1.88 were prescribed growth hormone therapy. 
      Forty-six percent of children with glomerular CKD were overweight or obese 
      (BMI-height-age >/= 85th percentile). CONCLUSIONS: Growth outcomes in a 
      contemporary cohort of children with CKD remain suboptimal. Interventions 
      targeting metabolic acidosis and overcoming barriers to recombinant human growth 
      hormone usage may improve growth in this population.
FAU - Rodig, Nancy M
AU  - Rodig NM
AD  - Division of Nephrology , Harvard Medical School-Children's Hospital Boston, 
      Boston, MA, 02115, USA, nancy.rodig@childrens.harvard.edu.
FAU - McDermott, Kelly C
AU  - McDermott KC
FAU - Schneider, Michael F
AU  - Schneider MF
FAU - Hotchkiss, Hilary M
AU  - Hotchkiss HM
FAU - Yadin, Ora
AU  - Yadin O
FAU - Seikaly, Mouin G
AU  - Seikaly MG
FAU - Furth, Susan L
AU  - Furth SL
FAU - Warady, Bradley A
AU  - Warady BA
LA  - eng
GR  - U01 DK066116/DK/NIDDK NIH HHS/United States
GR  - U01 DK066174/DK/NIDDK NIH HHS/United States
GR  - U01DK-082194/DK/NIDDK NIH HHS/United States
GR  - U01-DK-66143/DK/NIDDK NIH HHS/United States
GR  - U01-DK-66116/DK/NIDDK NIH HHS/United States
GR  - U01-DK-66174/DK/NIDDK NIH HHS/United States
GR  - U01 DK082194/DK/NIDDK NIH HHS/United States
GR  - U01 DK066143/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20140412
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
SB  - IM
MH  - Adolescent
MH  - *Body Height
MH  - *Body Mass Index
MH  - Body Weight
MH  - Cohort Studies
MH  - Female
MH  - Growth Disorders/*epidemiology
MH  - Humans
MH  - Male
MH  - Renal Insufficiency, Chronic/*complications
PMC - PMC4470271
MID - NIHMS693499
COIS- Conflict of Interest: The authors have no conflicts of interest to disclose.
EDAT- 2014/04/15 06:00
MHDA- 2015/06/03 06:00
PMCR- 2015/06/17
CRDT- 2014/04/15 06:00
PHST- 2013/10/15 00:00 [received]
PHST- 2014/03/14 00:00 [accepted]
PHST- 2014/02/13 00:00 [revised]
PHST- 2014/04/15 06:00 [entrez]
PHST- 2014/04/15 06:00 [pubmed]
PHST- 2015/06/03 06:00 [medline]
PHST- 2015/06/17 00:00 [pmc-release]
AID - 10.1007/s00467-014-2812-9 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2014 Oct;29(10):1987-95. doi: 10.1007/s00467-014-2812-9. Epub 
      2014 Apr 12.