PMID- 24728648
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 26
IP  - 4
DP  - 2014 Apr
TI  - HEAT-INDUCED TAS1 TARGET1 Mediates Thermotolerance via HEAT STRESS TRANSCRIPTION 
      FACTOR A1a-Directed Pathways in Arabidopsis.
PG  - 1764-1780
AB  - Many heat stress transcription factors (Hsfs) and heat shock proteins (Hsps) have 
      been identified to play important roles in the heat tolerance of plants. However, 
      many of the key factors mediating the heat response pathways remain unknown. 
      Here, we report that two genes, which are targets of TAS1 (trans-acting siRNA 
      precursor 1)-derived small interfering RNAs that we named HEAT-INDUCED TAS1 
      TARGET1 (HTT1) and HTT2, are involved in thermotolerance. Microarray analysis 
      revealed that the HTT1 and HTT2 genes were highly upregulated in Arabidopsis 
      thaliana seedlings in response to heat shock. Overexpression of TAS1a, whose 
      trans-acting small interfering RNAs target the HTT genes, elevated accumulation 
      of TAS1-siRNAs and reduced expression levels of the HTT genes, causing weaker 
      thermotolerance. By contrast, overexpression of HTT1 and HTT2 upregulated several 
      Hsf genes, leading to stronger thermotolerance. In heat-tolerant plants 
      overexpressing HsfA1a, the HTT genes were upregulated, especially at high 
      temperatures. Meanwhile, HsfA1a directly activated HTT1 and HTT2 through binding 
      to their promoters. HTT1 interacted with the heat shock proteins Hsp70-14 and 
      Hsp40 and NUCLEAR FACTOR Y, SUBUNIT C2. Taken together, these results suggest 
      that HTT1 mediates thermotolerance pathways because it is targeted by TAS1a, 
      mainly activated by HsfA1a, and acts as cofactor of Hsp70-14 complexes.
CI  - (c) 2014 American Society of Plant Biologists. All rights reserved.
FAU - Li, Shuxia
AU  - Li S
AD  - National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant 
      Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese 
      Academy of Sciences, Shanghai 200032, China.
FAU - Liu, Jinxin
AU  - Liu J
AD  - National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant 
      Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese 
      Academy of Sciences, Shanghai 200032, China.
FAU - Liu, Zhongyuan
AU  - Liu Z
AD  - National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant 
      Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese 
      Academy of Sciences, Shanghai 200032, China.
FAU - Li, Xiaorong
AU  - Li X
AD  - National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant 
      Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese 
      Academy of Sciences, Shanghai 200032, China.
FAU - Wu, Feijie
AU  - Wu F
AD  - National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant 
      Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese 
      Academy of Sciences, Shanghai 200032, China.
FAU - He, Yuke
AU  - He Y
AD  - National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant 
      Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese 
      Academy of Sciences, Shanghai 200032, China ykhe@sibs.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20140411
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
PMC - PMC4036584
EDAT- 2014/04/15 06:00
MHDA- 2014/04/15 06:01
PMCR- 2015/04/01
CRDT- 2014/04/15 06:00
PHST- 2014/04/15 06:00 [entrez]
PHST- 2014/04/15 06:00 [pubmed]
PHST- 2014/04/15 06:01 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - tpc.114.124883 [pii]
AID - 124883 [pii]
AID - 10.1105/tpc.114.124883 [doi]
PST - ppublish
SO  - Plant Cell. 2014 Apr;26(4):1764-1780. doi: 10.1105/tpc.114.124883. Epub 2014 Apr 
      11.