PMID- 2472965
OWN - NLM
STAT- MEDLINE
DCOM- 19890821
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 163
IP  - 1
DP  - 1989 Apr 12
TI  - Selective reduction of striatal type II glucocorticoid receptors in rats by 
      3,4-methylenedioxymethamphetamine (MDMA).
PG  - 157-61
AB  - A single 20 mg/kg dose of 3,4-methylenedioxymethamphetamine (MDMA) administered 
      to rats markedly decreased serotonin (5-HT) and 5-hydroxyindoleacetic acid 
      (5-HIAA) levels in hippocampus, frontal cortex and striatum seven days following 
      injection. MDMA also significantly decreased type II glucocorticoid receptor 
      levels in the striatum, but not in hippocampus or frontal cortex. Since no 
      difference in basal serum corticosterone levels was observed between the two 
      groups, MDMA may decrease striatal type II glucocorticoid receptors via a 
      corticosterone-independent mechanism.
FAU - Lowy, M T
AU  - Lowy MT
AD  - Department of Psychiatry, School of Medicine, Case Western Reserve University, 
      Cleveland, OH 44106.
FAU - Nash, J F Jr
AU  - Nash JF Jr
FAU - Meltzer, H Y
AU  - Meltzer HY
LA  - eng
GR  - MH 41684/MH/NIMH NIH HHS/United States
GR  - R03 MH 44339/MH/NIMH NIH HHS/United States
GR  - RR-05410-26/RR/NCRR NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Androstanols)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 74915-64-3 (11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Androstanols/pharmacology
MH  - Animals
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Corticosterone/blood
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Glucocorticoid/drug effects/*metabolism
MH  - Serotonin/metabolism
EDAT- 1989/04/12 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/04/12 00:00
PHST- 1989/04/12 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/04/12 00:00 [entrez]
AID - 0014-2999(89)90411-1 [pii]
AID - 10.1016/0014-2999(89)90411-1 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1989 Apr 12;163(1):157-61. doi: 10.1016/0014-2999(89)90411-1.