PMID- 24729844
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140414
LR  - 20220408
IS  - 2005-6419 (Print)
IS  - 2005-7563 (Electronic)
IS  - 2005-6419 (Linking)
VI  - 66
IP  - 3
DP  - 2014 Mar
TI  - Postoperative nausea and vomiting after total thyroidectomy: sevoflurane combined 
      with prophylactic ramosetron vs. propofol-based total intravenous anesthesia.
PG  - 216-21
LID - 10.4097/kjae.2014.66.3.216 [doi]
AB  - BACKGROUND: The frequent and distressing adverse events (AEs) of postoperative 
      nausea and vomiting (PONV) are of major concern in 63-84% of adult patients 
      undergoing thyroidectomy. We conducted this prospective study to compare two 
      prophylactic strategies; sevoflurane combined with ramosetron and propofol-based 
      total intravenous anesthesia in a homogenous group of non-smoking women 
      undergoing total thyroidectomy. METHODS: In the current prospective study, we 
      enrolled a consecutive series of 64 female patients aged between 20 and 65 years 
      with an American Society of Anesthesiologists physical status of I or II who were 
      scheduled to undergo elective total thyroidectomy under general anesthesia. 
      Patients were randomized to either the SR (sevoflurane and remifentanil) group or 
      the TIVA group. We evaluated the incidence and severity of PONV, the use of 
      rescue anti-emetics and the severity of pain during the first 24 h after surgery. 
      RESULTS: There were no significant differences in the proportion of the patients 
      with a complete response and the Rhodes index, including the occurrence score, 
      distress score and experience score, between the two groups. In addition, there 
      were no significant differences in the proportion of the patients who were in 
      need of rescue anti-emetics or analgesics and the VAS scores between the two 
      groups. CONCLUSIONS: In conclusion, TIVA and ramosetron prophylaxis reduced the 
      expected incidence of PONV in women undergoing total thyroidectomy. In addition, 
      there was no significant difference in the efficacy during the first 24 h 
      postoperatively between the two prophylactic regimens.
FAU - Park, Sang Hee
AU  - Park SH
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University, 
      Medical School, Gwangju, Korea.
FAU - Lee, Hyung Gon
AU  - Lee HG
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University, 
      Medical School, Gwangju, Korea.
FAU - Jeong, Chang Young
AU  - Jeong CY
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University, 
      Medical School, Gwangju, Korea.
FAU - Jeong, Seong Wook
AU  - Jeong SW
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University, 
      Medical School, Gwangju, Korea.
FAU - Lee, Seong Heon
AU  - Lee SH
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University, 
      Medical School, Gwangju, Korea.
FAU - Kim, Hwi Jin
AU  - Kim HJ
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University, 
      Medical School, Gwangju, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140328
PL  - Korea (South)
TA  - Korean J Anesthesiol
JT  - Korean journal of anesthesiology
JID - 101502451
PMC - PMC3983418
OTO - NOTNLM
OT  - Postoperative nausea and vomiting
OT  - Propofol
OT  - Ramosetron
OT  - Thyroidectomy
EDAT- 2014/04/15 06:00
MHDA- 2014/04/15 06:01
PMCR- 2014/03/01
CRDT- 2014/04/15 06:00
PHST- 2012/09/20 00:00 [received]
PHST- 2013/04/30 00:00 [revised]
PHST- 2013/05/14 00:00 [accepted]
PHST- 2014/04/15 06:00 [entrez]
PHST- 2014/04/15 06:00 [pubmed]
PHST- 2014/04/15 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 10.4097/kjae.2014.66.3.216 [doi]
PST - ppublish
SO  - Korean J Anesthesiol. 2014 Mar;66(3):216-21. doi: 10.4097/kjae.2014.66.3.216. 
      Epub 2014 Mar 28.