PMID- 24731781
OWN - NLM
STAT- MEDLINE
DCOM- 20150528
LR  - 20221207
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Linking)
VI  - 22
IP  - 10
DP  - 2014 Oct
TI  - Association of BDNF promoter methylation and genotype with suicidal ideation in 
      elderly Koreans.
PG  - 989-96
LID - S1064-7481(14)00081-5 [pii]
LID - 10.1016/j.jagp.2014.02.011 [doi]
AB  - OBJECTIVES: Brain-derived neurotrophic factor (BDNF) has been considered a risk 
      factor for suicidal behavior in adult populations. BDNF secretion is influenced 
      by epigenetic (DNA promoter methylation) and genetic (val66met polymorphism) 
      profiles. We investigated the independent and interactive effects of BDNF 
      methylation status and val66met polymorphisms on late-life suicidal ideation. 
      METHODS: In total, 732 Korean community residents aged 65+ years were evaluated; 
      of 639 without suicidal ideation, 579 (90.6%) were followed up 2 years later. The 
      prevalence and incidence of suicidal ideation were ascertained using the 
      Geriatric Mental State Schedule. Sociodemographic and clinical covariates 
      included age, sex, education, depressive symptoms, cognitive function, and 
      disability. The independent effects of BDNF methylation status on the prevalence 
      and incidence of suicidal ideation were investigated using multivariate logistic 
      regression models. The two-way interactions of BDNF methylation status and 
      val66met polymorphism on suicidal ideation were assessed using the same models. 
      RESULTS: Higher BDNF methylation status was significantly associated with both 
      prevalence and incidence of suicidal ideation, independent of potential 
      covariates. No significant methylation-genotype interaction was found. 
      CONCLUSIONS: The BDNF hypothesis and the epigenetic origin of the suicidal 
      behavior were supported, even in old age. BDNF promoter methylation status may be 
      useful as a biological marker for suicidality in late life.
CI  - Copyright (c) 2014 American Association for Geriatric Psychiatry. Published by 
      Elsevier Inc. All rights reserved.
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Korea.
FAU - Kang, Hee-Ju
AU  - Kang HJ
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Korea.
FAU - Bae, Kyung-Yeol
AU  - Bae KY
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Korea.
FAU - Kim, Sung-Wan
AU  - Kim SW
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Korea.
FAU - Shin, Il-Seon
AU  - Shin IS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Korea.
FAU - Kim, Hye-Ran
AU  - Kim HR
AD  - Brain Korea 21 Project, Center for Biomedical Human Resources, Chonnam National 
      University Medical School, Gwangju, Korea.
FAU - Shin, Myung-Geun
AU  - Shin MG
AD  - Department of Laboratory Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Yoon, Jin-Sang
AU  - Yoon JS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Korea. Electronic address: jsyoon@chonnam.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140304
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Asian People/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Methylation/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Korea
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - *Suicidal Ideation
OTO - NOTNLM
OT  - BDNF
OT  - DNA methylation
OT  - Suicidality
OT  - aged
OT  - epigenetics
EDAT- 2014/04/16 06:00
MHDA- 2015/05/29 06:00
CRDT- 2014/04/16 06:00
PHST- 2013/12/08 00:00 [received]
PHST- 2014/02/24 00:00 [revised]
PHST- 2014/02/27 00:00 [accepted]
PHST- 2014/04/16 06:00 [entrez]
PHST- 2014/04/16 06:00 [pubmed]
PHST- 2015/05/29 06:00 [medline]
AID - S1064-7481(14)00081-5 [pii]
AID - 10.1016/j.jagp.2014.02.011 [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2014 Oct;22(10):989-96. doi: 10.1016/j.jagp.2014.02.011. 
      Epub 2014 Mar 4.