PMID- 24732636
OWN - NLM
STAT- MEDLINE
DCOM- 20150126
LR  - 20140609
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 122
DP  - 2014 Jul
TI  - Effects of (+)-8-OH-DPAT on the duration of immobility during the forced swim 
      test and hippocampal cell proliferation in ACTH-treated rats.
PG  - 240-5
LID - S0091-3057(14)00110-5 [pii]
LID - 10.1016/j.pbb.2014.04.003 [doi]
AB  - In the present study, we examined the effect of ACTH on the immobilization of 
      rats in the forced swim test and hippocampal cell proliferation after 
      administration of the 5-HT1A receptor agonist, R-(+)-8-hydroxy-2-di-n-propylamino 
      tetralin ((+)-8-OH-DPAT). Chronic treatment with (+)-8-OH-DPAT (0.01-0.1 mg/kg, 
      s.c.) significantly decreased the duration of immobility in saline- and 
      ACTH-treated rats. Chronic administration of ACTH caused a significant decrease 
      in hippocampal cell proliferation. However, (+)-8-OH-DPAT significantly 
      normalized cell proliferation in ACTH-treated rats. We then investigated the 
      effects of (+)-8-OH-DPAT on the expression of brain-derived neurotrophic factor 
      (BDNF) and cyclin D1 (elements of cyclic adenosine monophosphate response 
      element-binding protein (CREB)-BDNF and Wnt signaling pathways, respectively) in 
      the hippocampus of saline- and ACTH-treated rats. ACTH treatment significantly 
      decreased the expression of cyclin D1, while treatment with (+)-8-OH-DPAT 
      normalized the expression of cyclin D1 in ACTH-treated rats. However, the 
      expression of BDNF did not change in either saline- or ACTH-treated rats. These 
      findings suggest that the antidepressant effects of (+)-8-OH-DPAT in 
      treatment-resistant animals may be attributed to an enhancement of hippocampal 
      cell proliferation, at least in part due to an enhancement of cyclin D1 
      expression.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Miyake, Ayaka
AU  - Miyake A
AD  - Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 
      700-8558, Japan.
FAU - Kitamura, Yoshihisa
AU  - Kitamura Y
AD  - Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 
      700-8558, Japan. Electronic address: kitamu-y@cc.okayama-u.ac.jp.
FAU - Miyazaki, Ikuko
AU  - Miyazaki I
AD  - Department of Brain Science, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 
      700-8558, Japan.
FAU - Asanuma, Masato
AU  - Asanuma M
AD  - Department of Brain Science, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 
      700-8558, Japan.
FAU - Sendo, Toshiaki
AU  - Sendo T
AD  - Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 
      700-8558, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140413
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Antidepressive Agents)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/*pharmacology/therapeutic use
MH  - Adrenocorticotropic Hormone/*toxicity
MH  - Animals
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Cell Proliferation/*drug effects/physiology
MH  - Depression/drug therapy/pathology/psychology
MH  - Hippocampus/cytology/*drug effects/physiology
MH  - Immobilization/physiology/*psychology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Swimming/*psychology
MH  - Time Factors
OTO - NOTNLM
OT  - 5-HT(1A) receptor
OT  - 8-OH-DPAT
OT  - Adrenocorticotropic hormone
OT  - Cell proliferation
OT  - Cyclin D1
OT  - Forced swim test
EDAT- 2014/04/16 06:00
MHDA- 2015/01/27 06:00
CRDT- 2014/04/16 06:00
PHST- 2014/01/15 00:00 [received]
PHST- 2014/03/10 00:00 [revised]
PHST- 2014/04/05 00:00 [accepted]
PHST- 2014/04/16 06:00 [entrez]
PHST- 2014/04/16 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
AID - S0091-3057(14)00110-5 [pii]
AID - 10.1016/j.pbb.2014.04.003 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2014 Jul;122:240-5. doi: 10.1016/j.pbb.2014.04.003. Epub 
      2014 Apr 13.