PMID- 24733715
OWN - NLM
STAT- MEDLINE
DCOM- 20160114
LR  - 20220408
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 19
IP  - 1
DP  - 2015 Mar
TI  - Short- and long-term effects of nocturnal oxygen therapy on sleep apnea in 
      chronic heart failure.
PG  - 159-68
LID - 10.1007/s11325-014-0982-0 [doi]
AB  - PURPOSE: This paper studies the short- and long-term effects of nocturnal oxygen 
      therapy (NOT) on sleep apnea in chronic heart failure (CHF). METHODS: We enrolled 
      51 adults in New York Heart Association (NYHA) heart failure functional classes 
      II or III, </=45 % left ventricular ejection fraction (LVEF), in a randomized, 
      open, single-center study. Nocturnal cardiorespiratory polygraphy showed sleep 
      apnea [apnea-hypopnea index (AHI) >/=15 events/h] in 33 patients, of whom 19 were 
      randomly assigned to NOT, 3.0 l/min, and 14 to no NOT. The NOT group underwent 
      follow-up polygraphy at 24 h and 6 months, and the no NOT group a single 
      follow-up polygraphy at 6 months. RESULTS: No significant difference was observed 
      between baseline and 6 months in the no NOT group. In the NOT group, AHI 
      decreased from 36.8 +/- 2.6 events/h at baseline to 20.8 +/- 3.0 at 24 h and to 
      18.3 +/- 2.4 at 6 months (both P < 0.0001 vs. baseline), due to central AHI changes 
      from 23.3 +/- 2.8 events/h at baseline to 8.3 +/- 1.6 at 24 h and to 6.1 +/- 1.4 at 
      6 months (both P < 0.0001 vs. baseline). Oxygen desaturation index (ODI) 
      decreased from 33.0 +/- 5.2 events/h at baseline to 7.5 +/- 0.5 at 24 h and 9.3 +/- 2.6 
      at 6 months (both P < 0.0001 vs. baseline). NOT had no significant effect on 
      obstructive and mixed AHI, quality of life (QOL), NYHA class, and LVEF up to 
      6 months of follow-up. CONCLUSIONS: NOT decreased central AHI and ODI 
      significantly within 24 h and up to 6 months in CHF patients with sleep apnea, 
      without significantly modifying obstructive and mixed AHI, QOL, and ventricular 
      function.
FAU - Bordier, Philippe
AU  - Bordier P
AD  - Cardiovascular Hospital of Haut-Leveque, 4eme Ouest, Avenue de Magellan, 33604, 
      Pessac Cedex, France, phibordier@aol.com.
FAU - Orazio, Sebastien
AU  - Orazio S
FAU - Hofmann, Pauline
AU  - Hofmann P
FAU - Robert, Frederic
AU  - Robert F
FAU - Bourenane, Ghalia
AU  - Bourenane G
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20140415
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnosis/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Inhalation Therapy/*methods
MH  - Polysomnography
MH  - Quality of Life
MH  - Sleep Apnea, Obstructive/diagnosis/physiopathology/*therapy
MH  - Ventricular Function, Left/physiology
EDAT- 2014/04/16 06:00
MHDA- 2016/01/15 06:00
CRDT- 2014/04/16 06:00
PHST- 2013/12/09 00:00 [received]
PHST- 2014/04/01 00:00 [accepted]
PHST- 2014/03/07 00:00 [revised]
PHST- 2014/04/16 06:00 [entrez]
PHST- 2014/04/16 06:00 [pubmed]
PHST- 2016/01/15 06:00 [medline]
AID - 10.1007/s11325-014-0982-0 [doi]
PST - ppublish
SO  - Sleep Breath. 2015 Mar;19(1):159-68. doi: 10.1007/s11325-014-0982-0. Epub 2014 
      Apr 15.