PMID- 24734242
OWN - NLM
STAT- MEDLINE
DCOM- 20151105
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Role of G protein-coupled receptors in control of dendritic cell migration.
PG  - 738253
LID - 10.1155/2014/738253 [doi]
LID - 738253
AB  - Dendritic cells (DCs) are highly efficient antigen-presenting cells. The 
      migratory properties of DCs give them the capacity to be a sentinel of the body 
      and the vital role in the induction and regulation of adaptive immune responses. 
      Therefore, it is important to understand the mechanisms in control of migration 
      of DCs to lymphoid and nonlymphoid tissues. This may provide us novel insight 
      into the clinical treatment of diseases such as autoimmune disease, infectious 
      disease, and tumor. The chemotactic G protein-coupled receptors (GPCR) play a 
      vital role in control of DCs migration. Here, we reviewed the recent advances 
      regarding the role of GPCR in control of migration of subsets of DCs, with a 
      focus on the chemokine receptors. Understanding subsets of DCs migration could 
      provide a rational basis for the design of novel therapies in various clinical 
      conditions.
FAU - Liu, Yuan
AU  - Liu Y
AD  - Department of Rheumatology and Clinical Immunology, The First Affiliated 
      Hospital, Xiamen University, No. 55, Zhenhai Road, Xiamen 361003, China.
FAU - Shi, Guixiu
AU  - Shi G
AD  - Department of Rheumatology and Clinical Immunology, The First Affiliated 
      Hospital, Xiamen University, No. 55, Zhenhai Road, Xiamen 361003, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140310
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Chemokines)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - *Cell Movement
MH  - Chemokines/metabolism
MH  - Dendritic Cells/*cytology
MH  - Humans
MH  - Ligands
MH  - Mice
MH  - Receptors, Chemokine/metabolism
MH  - Receptors, G-Protein-Coupled/*metabolism
MH  - Signal Transduction
PMC - PMC3966334
EDAT- 2014/04/16 06:00
MHDA- 2015/11/06 06:00
PMCR- 2014/03/10
CRDT- 2014/04/16 06:00
PHST- 2013/12/04 00:00 [received]
PHST- 2014/01/30 00:00 [revised]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/04/16 06:00 [entrez]
PHST- 2014/04/16 06:00 [pubmed]
PHST- 2015/11/06 06:00 [medline]
PHST- 2014/03/10 00:00 [pmc-release]
AID - 10.1155/2014/738253 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:738253. doi: 10.1155/2014/738253. Epub 2014 Mar 10.