PMID- 24734245
OWN - NLM
STAT- MEDLINE
DCOM- 20151105
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Digging up the human genome: current progress in deciphering adverse drug 
      reactions.
PG  - 824343
LID - 10.1155/2014/824343 [doi]
LID - 824343
AB  - Adverse drug reactions (ADRs) are a major clinical problem. In addition to their 
      clinical impact on human health, there is an enormous cost associated with ADRs 
      in health care and pharmaceutical industry. Increasing studies revealed that 
      genetic variants can determine the susceptibility of individuals to ADRs. The 
      development of modern genomic technologies has led to a tremendous advancement of 
      improving the drug safety and efficacy and minimizing the ADRs. This review will 
      discuss the pharmacogenomic techniques used to unveil the determinants of ADRs 
      and summarize the current progresses concerning the identification of biomarkers 
      for ADRs, with a focus on genetic variants for genes encoding drug-metabolizing 
      enzymes, drug-transporter proteins, and human leukocyte antigen (HLA). The 
      knowledge gained from these cutting-edge findings will form the basis for better 
      prediction and management for ADRs, ultimately making the medicine personalized.
FAU - Su, Shih-Chi
AU  - Su SC
AUID- ORCID: 0000-0002-4263-7654
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospital, 199 Tung-Hwa North Road, Taipei 105, Taiwan.
FAU - Chung, Wen-Hung
AU  - Chung WH
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospital, 199 Tung-Hwa North Road, Taipei 105, Taiwan ; 
      College of Medicine, Chang Gung University, 259 Wen-Hua First Road, Taoyuan 333, 
      Taiwan.
FAU - Hung, Shuen-Iu
AU  - Hung SI
AUID- ORCID: 0000-0001-6531-5538
AD  - Institute of Pharmacology, School of Medicine, Infection and Immunity Research 
      Center, VYM Genome Research Center, National Yang-Ming University, No. 155, 
      Section 2, Linong Street, Taipei 112, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140310
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Adverse Drug Reaction Reporting Systems
MH  - Biological Transport
MH  - Biomarkers/metabolism
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Genetic Variation
MH  - *Genome, Human
MH  - Genomics
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Pharmacogenetics
MH  - Phenotype
MH  - Sequence Analysis, DNA
PMC - PMC3966344
EDAT- 2014/04/16 06:00
MHDA- 2015/11/06 06:00
PMCR- 2014/03/10
CRDT- 2014/04/16 06:00
PHST- 2013/12/13 00:00 [received]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/04/16 06:00 [entrez]
PHST- 2014/04/16 06:00 [pubmed]
PHST- 2015/11/06 06:00 [medline]
PHST- 2014/03/10 00:00 [pmc-release]
AID - 10.1155/2014/824343 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:824343. doi: 10.1155/2014/824343. Epub 2014 Mar 10.