PMID- 24734867
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20140519
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Linking)
VI  - 10
IP  - 6
DP  - 2014 Jun
TI  - Future considerations for dendritic cell immunotherapy against chronic viral 
      infections.
PG  - 801-13
LID - 10.1586/1744666X.2014.907742 [doi]
AB  - Dendritic cells (DCs) are multifunctional cells that are pivotal in immune 
      defense. As such they have been explored as vaccine carriers, largely in cancer 
      immunotherapy and against some infectious diseases including HIV and viral 
      hepatitis. However, while the use of DCs as vaccine carrier has shown some 
      promise in cancer immunotherapy, this approach is laborious and is subject to 
      strict quality control, which makes it expensive. Furthermore, in some 
      individuals chronically infected with HIV, HCV and/or HBV the numbers of 
      circulating DCs are reduced and/or their functions impaired. In vivo expansion 
      and mobilization of DCs with Flt3L in combination with antigen and/or adjuvant 
      targeting to critical DC receptors may be a more effective approach to control 
      viral replication in chronically infected HIV, HBV and/or HCV patients than 
      current DC immunotherapy approaches.
FAU - Atanley, Ethel
AU  - Atanley E
AD  - VIDO-Intervac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK, 
      S7N 5E3, Canada.
FAU - van Drunen Littel-van den Hurk, Sylvia
AU  - van Drunen Littel-van den Hurk S
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140416
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
SB  - IM
MH  - Animals
MH  - Chronic Disease
MH  - Dendritic Cells/*immunology
MH  - HIV Infections/immunology/*therapy
MH  - Hepatitis B, Chronic/immunology/*therapy
MH  - Hepatitis C, Chronic/immunology/*therapy
MH  - Humans
MH  - Immunotherapy/*methods
OTO - NOTNLM
OT  - Flt3L
OT  - HBV immunotherapy
OT  - HCV
OT  - HIV
OT  - dendritic cells
OT  - endocytic receptors
EDAT- 2014/04/17 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/04/17 06:00
PHST- 2014/04/17 06:00 [entrez]
PHST- 2014/04/17 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - 10.1586/1744666X.2014.907742 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2014 Jun;10(6):801-13. doi: 
      10.1586/1744666X.2014.907742. Epub 2014 Apr 16.