PMID- 24736012
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20140604
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 110
IP  - 1
DP  - 2014 Jun
TI  - Detection of donor-specific antibodies in kidney transplantation.
PG  - 23-34
LID - 10.1093/bmb/ldu005 [doi]
AB  - INTRODUCTION: Precise and timely detection of human leukocyte antigen (HLA) 
      donor-specific antibodies (DSAs) is vital for evaluating humoral immune status of 
      patients pre- and post-transplantation. SOURCE OF DATA: Clinically relevant 
      articles on theory, development, methodology and application of HLA-DSA testing 
      in kidney transplantation. AREAS OF AGREEMENT AND CONTROVERSY: The availability 
      of solid phase HLA-antibody testing revolutionized our ability to detect HLA-DSA 
      and to appreciate their significance in kidney transplant outcome. The best 
      approach to determine the strength, immunogenicity and pathogenicity of HLA 
      antibodies still remains controversial. GROWING POINTS: Assays to identify 
      complement-binding antibodies were developed. Their clinical utilization, pre- 
      and post-transplantation, is currently under investigation. Appreciation of the 
      complexity of HLA-DQ antibodies should lead to better assignment of unacceptable 
      antibodies and cPRA calculation. AREAS TIMELY FOR DEVELOPING RESEARCH: 
      Characterization of HLA-antibody epitopes, and utilization of epitope matching to 
      better define compatible donors could contribute to better transplant outcomes.
CI  - (c) The Author 2014. Published by Oxford University Press. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Haarberg, Kelley M K
AU  - Haarberg KM
AD  - Transplant Immunology Laboratory, Comprehensive Transplant Center, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL, USA.
FAU - Tambur, Anat R
AU  - Tambur AR
AD  - Transplant Immunology Laboratory, Comprehensive Transplant Center, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL, USA 
      a-tambur@northwestern.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140415
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Complement System Proteins/metabolism
MH  - Graft Rejection/immunology
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Immunoassay/methods
MH  - Isoantibodies/*blood
MH  - *Kidney Transplantation
MH  - Prognosis
MH  - *Tissue Donors
OTO - NOTNLM
OT  - C1q
OT  - HLA-DQ antibodies
OT  - HLA-antibody epitope
OT  - complement-binding antibodies
OT  - donor-specific antibodies
OT  - prozone
OT  - solid-phase assays
EDAT- 2014/04/17 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/04/17 06:00
PHST- 2014/04/17 06:00 [entrez]
PHST- 2014/04/17 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - ldu005 [pii]
AID - 10.1093/bmb/ldu005 [doi]
PST - ppublish
SO  - Br Med Bull. 2014 Jun;110(1):23-34. doi: 10.1093/bmb/ldu005. Epub 2014 Apr 15.