PMID- 24736051
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20220317
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 5
DP  - 2014 May 8
TI  - Preservation of the photoreceptor layer following subthreshold laser treatment 
      for diabetic macular edema as demonstrated by SD-OCT.
PG  - 3054-9
LID - 10.1167/iovs.13-12607 [doi]
AB  - PURPOSE: Subthreshold laser treatment of diabetic macular edema (DME) may have 
      less deleterious effects on the photoreceptors than regular continuous wave 
      laser. This study aimed to assess whether subthreshold laser causes a long-term 
      damage to the retinal structures, as demonstrated by spectral-domain optical 
      coherence tomography (SD-OCT), and to evaluate the change in the axial diameter 
      of retinal diabetic microaneurysms following treatment. METHODS: A retrospective 
      study of eyes that were diagnosed with nonfoveal involving DME and underwent 
      subthreshold laser treatment with the Novus SRT system. Spectral-domain OCT scans 
      of treated retinal areas, performed prior to treatment and approximately 4 months 
      following treatment, were assessed for changes in the continuity of the 
      photoreceptor (PR) layer, the thickness of the PR-RPE layer, the retinal 
      thickness at the treatment sites, and the diameter of the microaneurysms. 
      RESULTS: Included in this study were 31 microaneurysms. Following treatment, the 
      continuity of the ellipsoid zone of the inner segments of the photoreceptors was 
      confirmed in all but two cases. The thickness of the PR-RPE layers was 72.32 +/- 
      7.36 and 70.97 +/- 7.27 mum prior to and following treatment, respectively (P = 
      0.061). The retinal thickness at the treatment sites decreased from 398.65 +/- 
      57.89 to 372.74 +/- 60.4 mum (P < 0.001). The mean measured diameter of the 
      microaneurysms was 87.32 +/- 27.45 and 6.68 +/- 26.12 mum, respectively (P < 0.001). 
      CONCLUSIONS: In this study, subthreshold laser treatment for DME has been shown 
      to be a safe technology that preserves the photoreceptor layer, as demonstrated 
      by SD-OCT.
FAU - Soiberman, Uri
AU  - Soiberman U
AD  - Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Goldstein, Michaella
AU  - Goldstein M
FAU - Pianka, Pazit
AU  - Pianka P
FAU - Loewenstein, Anat
AU  - Loewenstein A
FAU - Goldenberg, Dafna
AU  - Goldenberg D
LA  - eng
PT  - Journal Article
DEP - 20140508
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aneurysm/pathology
MH  - Diabetic Retinopathy/pathology/*surgery
MH  - Female
MH  - Humans
MH  - *Laser Coagulation/adverse effects
MH  - Macular Edema/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Organ Sparing Treatments/methods
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Retinal Pigment Epithelium/pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - microaneurysms
OT  - optical coherence tomography
OT  - photoreceptors
OT  - retinal pigment epithelium
OT  - subthreshold laser treatmsent
EDAT- 2014/04/17 06:00
MHDA- 2014/06/24 06:00
CRDT- 2014/04/17 06:00
PHST- 2014/04/17 06:00 [entrez]
PHST- 2014/04/17 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
AID - iovs.13-12607 [pii]
AID - 10.1167/iovs.13-12607 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 May 8;55(5):3054-9. doi: 10.1167/iovs.13-12607.