PMID- 2473624
OWN - NLM
STAT- MEDLINE
DCOM- 19890821
LR  - 20190824
IS  - 0065-4299 (Print)
IS  - 0065-4299 (Linking)
VI  - 27
IP  - 1-2
DP  - 1989 Apr
TI  - Serum levels of neutrophil and eosinophil chemotactic activities in mastocytosis.
PG  - 208-11
AB  - Neutrophil and eosinophil chemotactic activities (NCA and ECA) were measured in 
      serum from twenty-two patients with urticaria pigmentosa or systemic 
      mastocytosis. NCA was also measured after heating serum to 56 degrees C 
      (heat-stable NCA). Although these factors were increased in about half of the 
      patients there was no correlation with histamine release as estimated by the 
      excretion of the main histamine metabolite methylimidazoleacetic acid (MelmAA) in 
      urine. A significant increase in heat-stable NCA, however, was found in patients 
      with pruritus and abnormal high values of MelmAA. It is concluded that only 
      heat-stable NCA is a specific mast cell mediator, but that the heat-labile NCA 
      and ECA are dependent on mast cells for their production by a different cell, 
      tentatively identified as the macrophage.
FAU - Granerus, G
AU  - Granerus G
AD  - Department of Clinical Physiology, University Hospital, Linkoping, Sweden.
FAU - Hakansson, L
AU  - Hakansson L
FAU - Roupe, G
AU  - Roupe G
FAU - Venge, P
AU  - Venge P
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Agents Actions
JT  - Agents and actions
JID - 0213341
RN  - 0 (Chemotactic Factors)
RN  - 0 (Chemotactic Factors, Eosinophil)
RN  - 0 (Imidazoles)
RN  - 0 (Interleukin-8)
RN  - 2625-49-2 (methylimidazoleacetic acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemotactic Factors/*blood
MH  - Chemotactic Factors, Eosinophil/*blood
MH  - Histamine Release
MH  - Humans
MH  - Imidazoles/urine
MH  - Interleukin-8
MH  - Mast Cells/metabolism
MH  - Mastocytosis/*blood/physiopathology
MH  - Middle Aged
MH  - Urticaria Pigmentosa/blood/physiopathology
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1007/BF02222241 [doi]
PST - ppublish
SO  - Agents Actions. 1989 Apr;27(1-2):208-11. doi: 10.1007/BF02222241.