PMID- 24736679
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20211021
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Print)
IS  - 0954-3007 (Linking)
VI  - 68
IP  - 9
DP  - 2014 Sep
TI  - Impact of stearic acid and oleic acid on hemostatic factors in the context of 
      controlled diets consumed by healthy men.
PG  - 1072-4
LID - 10.1038/ejcn.2014.62 [doi]
AB  - The effects of stearic acid (STA) on cardiovascular disease risk beyond lipid and 
      lipoprotein risk factors, including hemostasis, are unclear, particularly when 
      compared with unsaturated fatty acids. The aim of the present study is to compare 
      the effects of STA with those of oleic acid (OL) on markers of hemostasis. In a 
      randomized crossover study, 50 men consumed six controlled diets for 5 weeks each 
      (39% energy from fat, 15% energy from protein, 46% energy from carbohydrate 
      (CHO)). Fat (8% energy) was replaced across diets by: STA, OL, CHO (control), 
      trans fatty acids (TFAs), TFA/STA and 12:0-16:0 saturated fatty acids. Factor 
      VIIc, plasminogen activator inhibitor-1 (PAI-1) and plasmin alpha-2-antiplasmin 
      complex concentrations were not different between OL and STA (P>0.05). Compared 
      with control, OL increased factor VIIc and PAI-1 (P</=0.05), whereas there were no 
      differences with STA (P>0.05). STA and OL similarly affect markers of hemostasis 
      in healthy men, within the context of a highly controlled diet.
FAU - Gebauer, S K
AU  - Gebauer SK
AD  - USDA, Agricultural Research Service, Beltsville Human Nutrition Research Center, 
      Beltsville, MD, USA.
FAU - Tracy, R P
AU  - Tracy RP
AD  - Department of Pathology, University of Vermont College of Medicine, Colchester, 
      VT, USA.
FAU - Baer, D J
AU  - Baer DJ
AD  - USDA, Agricultural Research Service, Beltsville Human Nutrition Research Center, 
      Beltsville, MD, USA.
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140416
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Blood Coagulation Factors)
RN  - 0 (Dietary Fats)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Stearic Acids)
RN  - 0 (alpha-2-Antiplasmin)
RN  - 0 (plasmin-plasmin inhibitor complex)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - 4ELV7Z65AP (stearic acid)
RN  - 9001-25-6 (Factor VII)
RN  - EC 3.4.21.7 (Fibrinolysin)
SB  - IM
MH  - Adult
MH  - Blood Coagulation Factors/*metabolism
MH  - Cross-Over Studies
MH  - *Diet
MH  - Dietary Fats/*pharmacology
MH  - Energy Intake
MH  - Factor VII/metabolism
MH  - Fibrinolysin/*metabolism
MH  - *Hemostasis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oleic Acid/*pharmacology
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Reference Values
MH  - Stearic Acids/*pharmacology
MH  - alpha-2-Antiplasmin/*metabolism
PMC - PMC4155798
EDAT- 2014/04/17 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/04/17 06:00
PHST- 2013/09/05 00:00 [received]
PHST- 2014/02/10 00:00 [revised]
PHST- 2014/02/27 00:00 [accepted]
PHST- 2014/04/17 06:00 [entrez]
PHST- 2014/04/17 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - ejcn201462 [pii]
AID - 10.1038/ejcn.2014.62 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2014 Sep;68(9):1072-4. doi: 10.1038/ejcn.2014.62. Epub 2014 Apr 
      16.