PMID- 24737445
OWN - NLM
STAT- MEDLINE
DCOM- 20141230
LR  - 20201209
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Linking)
VI  - 34
IP  - 1
DP  - 2014 Jul
TI  - Estrogen is a novel regulator of Tnfaip1 in mouse hippocampus.
PG  - 219-27
LID - 10.3892/ijmm.2014.1742 [doi]
AB  - Tumor necrosis factor‑induced protein 1 (Tnfaip1), also known as B12, has been 
      previously identified as a tumor necrosis factor-alpha (TNF-alpha)-inducible protein and 
      is involved in the cytokinesis signaling pathway, DNA synthesis, innate immunity, 
      cell apoptosis, Alzheimer's disease (AD) and type 2 diabetic nephropathy. 
      However, little is known regarding the expression of Tnfaip1 in various tissues 
      or its accurate role in these physiological functions. The focus of this study 
      was on Tnfaip1 expression in different tissues, with a high expression in mouse 
      hippocampus being identified. The age- and gender‑related expression of Tnfaip1 
      in hippocampus was also investigated. The distribution of Tnfaip1 was mapped 
      using fluorescent immunostaining. Although immunoactivity was found in the CA1, 
      CA3 and DG subregions of the hippocampus in E17.5 and P6 mice, strong staining 
      was only detected in the CA3 subregion in adult mice. These data suggested that 
      Tnfaip1 expression in hippocampus may be regulated by estrogen. Further study 
      showed that the expression of Tnfaip1 in the hippocampus was significantly 
      increased in ovariecto-mized mice compared to Sham mice. In cultured primary 
      hippocampal cells, Tnfaip1 showed different expression levels in different 
      treatments of estrogen or estrogen receptor antagonists. Additional experiments 
      demonstrated the existence of a binding site of ERbeta in the Tnfaip1 promoter 
      region, and that ERbeta was able to upregulate Tnfaip1 expression. Our study 
      identified a new regulatory factor and a primary regulatory mechanism of Tnfaip1 
      expression in hippocampus. Since both hippocampus and estrogen are crucial in AD, 
      the results also showed a potential association between Tnfaip1 and 
      hippocampal-related diseases, such as AD, which may be affected by the estrogen 
      level.
FAU - Liu, Hui
AU  - Liu H
AD  - Department of Life Science, Hunan Agricultural University, Changsha, Hunan 
      410128, P.R. China.
FAU - Yang, Liping
AU  - Yang L
AD  - Department of Enviromental Science, Changsha Environmental Protection College, 
      Changsha, Hunan 410004, P.R. China.
FAU - Zhao, Yingchun
AU  - Zhao Y
AD  - Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, 
      LA 70112, USA.
FAU - Zeng, Guihua
AU  - Zeng G
AD  - Department of Enviromental Science, Changsha Environmental Protection College, 
      Changsha, Hunan 410004, P.R. China.
FAU - Wu, Yaosong
AU  - Wu Y
AD  - Laboratory of Molecular Biology, Henan University of Traditional Chinese 
      Medicine, Zhengzhou, Henan 410208, P.R. China.
FAU - Chen, Yulong
AU  - Chen Y
AD  - Laboratory of Molecular Biology, Henan University of Traditional Chinese 
      Medicine, Zhengzhou, Henan 410208, P.R. China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Key Laboratory of Protein Chemistry and Developmental Biology, Ministry of 
      Education of China, Department of Biochemistry and Molecular Biology, College of 
      Life Science, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
FAU - Zeng, Qingru
AU  - Zeng Q
AD  - Department of Life Science, Hunan Agricultural University, Changsha, Hunan 
      410128, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140411
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Proteins)
RN  - 0 (Tnfaip1 protein, mouse)
RN  - 22X328QOC4 (Fulvestrant)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Administration, Oral
MH  - Age Factors
MH  - Animals
MH  - Embryo, Mammalian
MH  - Estradiol/analogs & derivatives/metabolism/*pharmacology
MH  - Estrogen Receptor beta/antagonists & inhibitors/*genetics/metabolism
MH  - Female
MH  - Fulvestrant
MH  - *Gene Expression Regulation, Developmental
MH  - Hippocampus/cytology/*drug effects/growth & development/metabolism
MH  - Intracellular Signaling Peptides and Proteins
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurons/cytology/*drug effects/metabolism
MH  - Ovariectomy
MH  - Primary Cell Culture
MH  - Promoter Regions, Genetic
MH  - Proteins/*genetics/metabolism
MH  - Sex Factors
MH  - Signal Transduction
EDAT- 2014/04/17 06:00
MHDA- 2014/12/31 06:00
CRDT- 2014/04/17 06:00
PHST- 2013/11/02 00:00 [received]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/04/17 06:00 [entrez]
PHST- 2014/04/17 06:00 [pubmed]
PHST- 2014/12/31 06:00 [medline]
AID - 10.3892/ijmm.2014.1742 [doi]
PST - ppublish
SO  - Int J Mol Med. 2014 Jul;34(1):219-27. doi: 10.3892/ijmm.2014.1742. Epub 2014 Apr 
      11.