PMID- 2473763
OWN - NLM
STAT- MEDLINE
DCOM- 19890829
LR  - 20191029
IS  - 0896-8411 (Print)
IS  - 0896-8411 (Linking)
VI  - 2
IP  - 1
DP  - 1989 Feb
TI  - Immunotherapy of experimental autoimmune encephalomyelitis (EAE): differential 
      effect of anti-IL-2 receptor antibody therapy on actively induced and T-line 
      mediated EAE of the Lewis rat.
PG  - 61-73
AB  - Treatment of Lewis rats with monoclonal anti-interleukin-2 receptor (IL-2 R) 
      antibody ART-18 is highly efficient in protecting the recipients from T-line 
      transferred experimental autoimmune encephalomyelitis (tEAE) in vivo. In 
      contrast, ART-18 did not affect the development of EAE actively induced (aEAE) by 
      immunization with myelin basic protein (MBP) in complete Freund's adjuvant (CFA). 
      ART-18 caused a slight delay in the development of aEAE only in combination with 
      a subtherapeutic dose of cyclosporine A (Cy-A), but failed to influence duration 
      or severity of clinical signs. The discrepancy in therapeutic efficiency of 
      ART-18 in tEAE and aEAE could be due to a different intensity of IL-2 
      R-expression on in vitro- and in vivo-activated MBP-specific T cells. Our results 
      therefore caution against a general therapeutic application of anti IL-2 
      R-directed therapy in all manifestations of T-cell-mediated autoimmunity.
FAU - Engelhardt, B
AU  - Engelhardt B
AD  - Max-Planck-Gesellschaft, Klinische Forschungsgruppe fur Multiple Sklerose, 
      Wurzburg, FRG.
FAU - Diamantstein, T
AU  - Diamantstein T
FAU - Wekerle, H
AU  - Wekerle H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Autoimmun
JT  - Journal of autoimmunity
JID - 8812164
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Cyclosporins)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*therapeutic use
MH  - Autoimmune Diseases/drug therapy/*therapy
MH  - Combined Modality Therapy
MH  - Cyclosporins/therapeutic use
MH  - Encephalomyelitis, Autoimmune, Experimental/drug therapy/etiology/*therapy
MH  - Female
MH  - Immunization
MH  - Immunization, Passive
MH  - Myelin Basic Protein/toxicity
MH  - Rats
MH  - Rats, Inbred Lew/immunology
MH  - Receptors, Interleukin-2/*immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology/transplantation
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
AID - 0896-8411(89)90108-X [pii]
AID - 10.1016/0896-8411(89)90108-x [doi]
PST - ppublish
SO  - J Autoimmun. 1989 Feb;2(1):61-73. doi: 10.1016/0896-8411(89)90108-x.