PMID- 24738557
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20220408
IS  - 1948-7193 (Electronic)
IS  - 1948-7193 (Print)
IS  - 1948-7193 (Linking)
VI  - 5
IP  - 6
DP  - 2014 Jun 18
TI  - Lithium and autophagy.
PG  - 434-42
LID - 10.1021/cn500056q [doi]
AB  - Lithium, a drug used to treat bipolar disorders, has a variety of neuroprotective 
      mechanisms, including autophagy regulation, in various neuropsychiatric 
      conditions. In neurodegenerative diseases, lithium enhances degradation of 
      aggregate-prone proteins, including mutated huntingtin, phosphorylated tau, and 
      alpha-synuclein, and causes damaged mitochondria to degrade, while in a mouse model 
      of cerebral ischemia and Alzheimer's disease autophagy downregulation by lithium 
      is observed. The signaling pathway of lithium as an autophagy enhancer might be 
      associated with the mammalian target of rapamycin (mTOR)-independent pathway, 
      which is involved in myo-inositol-1,4,5-trisphosphate (IP3) in Huntington's 
      disease and Parkinson's disease. However, the mTOR-dependent pathway might be 
      involved in inhibiting glycogen synthase kinase-3beta (GSK3beta) in other diseases. 
      Lithium's autophagy-enhancing property may contribute to the therapeutic benefit 
      of patients with neuropsychiatric disorders.
FAU - Motoi, Yumiko
AU  - Motoi Y
AD  - daggerDepartment of Diagnosis, Prevention and Treatment of Dementia, double daggerDepartment of 
      Neurology, and  section signDepartment of Pharmacy, Juntendo University School of Medicine, 
      Tokyo 113-8421, Japan.
FAU - Shimada, Kohei
AU  - Shimada K
AD  - daggerDepartment of Diagnosis, Prevention and Treatment of Dementia, double daggerDepartment of 
      Neurology, and  section signDepartment of Pharmacy, Juntendo University School of Medicine, 
      Tokyo 113-8421, Japan.
FAU - Ishiguro, Koichi
AU  - Ishiguro K
AD  - daggerDepartment of Diagnosis, Prevention and Treatment of Dementia, double daggerDepartment of 
      Neurology, and  section signDepartment of Pharmacy, Juntendo University School of Medicine, 
      Tokyo 113-8421, Japan.
FAU - Hattori, Nobutaka
AU  - Hattori N
AD  - daggerDepartment of Diagnosis, Prevention and Treatment of Dementia, double daggerDepartment of 
      Neurology, and  section signDepartment of Pharmacy, Juntendo University School of Medicine, 
      Tokyo 113-8421, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140430
PL  - United States
TA  - ACS Chem Neurosci
JT  - ACS chemical neuroscience
JID - 101525337
RN  - 0 (Lithium Compounds)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Autophagy/*drug effects
MH  - Humans
MH  - Lithium Compounds/*pharmacology
MH  - Nervous System Diseases/drug therapy/physiopathology
MH  - Neuroprotective Agents/*pharmacology
PMC - PMC4063500
OTO - NOTNLM
OT  - GSK3beta, IMPase
OT  - Huntingtin
OT  - Lithium
OT  - autophagy
OT  - prion protein
OT  - tau
OT  - alpha-synuclein
EDAT- 2014/04/18 06:00
MHDA- 2015/10/09 06:00
PMCR- 2015/06/18
CRDT- 2014/04/18 06:00
PHST- 2014/04/18 06:00 [entrez]
PHST- 2014/04/18 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
PHST- 2015/06/18 00:00 [pmc-release]
AID - 10.1021/cn500056q [doi]
PST - ppublish
SO  - ACS Chem Neurosci. 2014 Jun 18;5(6):434-42. doi: 10.1021/cn500056q. Epub 2014 Apr 
      30.