PMID- 24741517
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140417
LR  - 20211021
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 18
IP  - 2
DP  - 2014 Mar
TI  - The potential impact of family history of metabolic syndrome and risk of type 2 
      diabetes mellitus: In a highly endogamous population.
PG  - 202-9
LID - 10.4103/2230-8210.129112 [doi]
AB  - AIM: This study aims to determine the potential impact of positive family history 
      of Metabolic Syndrome (MetS) among two generations, on developing Type 2 Diabetes 
      Mellitus (T2DM) and the potential relation of consanguineous marriage among 
      patients with MetS to the risk of developing T2DM among a sample of Qataris. 
      DESIGN: A cross-sectional study. SETTING: Primary healthcare (PHC) centers. 
      MATERIALS AND METHODS: The survey and measurement were conducted from April 2011 
      to December 2012 among Qatari nationals above 20 years of age. Of the 2,182 
      subjects, who were approached to participate in the study, 1,552 (71%) gave their 
      consent. Face-to-face interviews were conducted using a structured questionnaire 
      followed by anthropometric measurements and laboratory tests. Metabolic syndrome 
      was defined using the National Cholesterol Education Program-Third Adult 
      Treatment Panel (ATP III) as well as International Diabetes Federation (IDF). 
      RESULTS: Overall, the prevalence of MetS was 26.2% according to ATP III and 36.9% 
      according to IDF (P < 0.0001). The mean age of MetS patients with T2DM was 
      significantly higher than those without T2DM (Mean 48 +/- 9.9 vs. 42.5 +/- 9.2; P < 
      0.001). The proportion of females was higher among MetS patients with T2DM as 
      compared to those without T2DM (61% vs. 51%; P = 0.053). In addition, there were 
      significant differences between MetS patients with and without DM in terms of 
      co-morbidities of hypertension, coronary heart disease, and high cholesterol. The 
      proportion of MetS patients with positive family history for MetS was 
      significantly higher in MetS patients with T2DM as compared to those without T2DM 
      (46.7% vs. 33.8%; P = 0.009). The proportion of positive family history of MetS 
      among fathers (35% vs. 21.9%; P = 0.005), mothers (30.5% vs. 18.8%; P = 0.008), 
      maternal aunt (18.3% vs. 11.2%; P = 0.055), and maternal grand father (19.5% vs. 
      10%; P = 0.010) were significantly higher in MetS patients with T2DM as compared 
      to the counterpart. The proportion of consanguineous marriages was almost two 
      times higher among MetS patients with T2DM as compared to those without T2DM 
      (80.9% vs. 41.9%; P < 0.001). The proportion of MetS patients with T2DM was lower 
      than MetS patients without DM below 45 years, but after 45 years, the proportion 
      of MetS patients with T2DM remained higher than their counterparts. CONCLUSION: 
      Family history of MetS among parents, maternal aunt, maternal grandfather, and 
      consanguineous marriages among patients of MetS are significantly associated with 
      the development of T2DM in Qatar. These results support the necessity of earlier 
      screening for T2DM among MetS patients with positive family history of MetS.
FAU - Bener, Abdulbari
AU  - Bener A
AD  - Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, 
      London, UK ; Department of Public Health, Weill Cornell Medical College, Doha, 
      Qatar, London, UK ; Department of Evidence for Population Health Unit, School of 
      Epidemiology and Health Sciences, The University of Manchester, Manchester, UK.
FAU - Darwish, Sarah
AU  - Darwish S
AD  - Department of Endocrinology, Hamad General Hospital, Hamad Medical Corporation, 
      Doha, Qatar, London, UK.
FAU - Al-Hamaq, Abdulla O A
AU  - Al-Hamaq AO
AD  - Department of Qatar Diabetic Association and Qatar Foundation, Doha, Qatar, 
      London, UK.
FAU - Yousafzai, Mohammad T
AU  - Yousafzai MT
AD  - Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, 
      London, UK ; Department of Public Health, Weill Cornell Medical College, Doha, 
      Qatar, London, UK.
FAU - Nasralla, Eman A
AU  - Nasralla EA
AD  - Division of Epidemiology and Public Health, Imperial College London, London, UK.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC3987271
OTO - NOTNLM
OT  - Consanguinity
OT  - correlates
OT  - diabetes mellitus
OT  - genetics
OT  - metabolic syndrome
OT  - prevalence
COIS- Conflict of Interest: None declared.
EDAT- 2014/04/18 06:00
MHDA- 2014/04/18 06:01
PMCR- 2014/03/01
CRDT- 2014/04/18 06:00
PHST- 2014/04/18 06:00 [entrez]
PHST- 2014/04/18 06:00 [pubmed]
PHST- 2014/04/18 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - IJEM-18-202 [pii]
AID - 10.4103/2230-8210.129112 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2014 Mar;18(2):202-9. doi: 10.4103/2230-8210.129112.