PMID- 24741591
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20240324
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - Adipokines, metabolic syndrome and rheumatic diseases.
PG  - 343746
LID - 10.1155/2014/343746 [doi]
LID - 343746
AB  - The metabolic syndrome (MetS) is a cluster of cardiometabolic disorders that 
      result from the increasing prevalence of obesity. The major components of MetS 
      include insulin resistance, central obesity, dyslipidemia, and hypertension. MetS 
      identifies the central obesity with increased risk for cardiovascular diseases 
      (CVDs) and type-2 diabetes mellitus (T2DM). Patients with rheumatic diseases, 
      such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and 
      ankylosing spondylitis, have increased prevalence of CVDs. Moreover, CVD risk is 
      increased when obesity is present in these patients. However, traditional 
      cardiovascular risk factors do not completely explain the enhanced cardiovascular 
      risk in this population. Thus, MetS and the altered secretion patterns of 
      proinflammatory adipokines present in obesity could be the link between CVDs and 
      rheumatic diseases. Furthermore, adipokines have been linked to the pathogenesis 
      of MetS and its comorbidities through their effects on vascular function and 
      inflammation. In the present paper, we review recent evidence of the role played 
      by adipokines in the modulation of MetS in the general population, and in 
      patients with rheumatic diseases.
FAU - Abella, Vanessa
AU  - Abella V
AD  - SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in 
      Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), 
      Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain ; 
      Department of Molecular and Cellular Biology, University of Coruna (UDC), 15071 A 
      Coruna, Spain.
FAU - Scotece, Morena
AU  - Scotece M
AD  - SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in 
      Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), 
      Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain.
FAU - Conde, Javier
AU  - Conde J
AUID- ORCID: 0000-0002-1007-5669
AD  - SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in 
      Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), 
      Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain.
FAU - Lopez, Veronica
AU  - Lopez V
AD  - SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in 
      Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), 
      Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain.
FAU - Lazzaro, Veronica
AU  - Lazzaro V
AD  - SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in 
      Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), 
      Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain ; 
      University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
FAU - Pino, Jesus
AU  - Pino J
AD  - SERGAS, Division of Orthopaedics Surgery and Traumatology, Santiago University 
      Clinical Hospital, 15706 Santiago de Compostela, Spain.
FAU - Gomez-Reino, Juan J
AU  - Gomez-Reino JJ
AD  - SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in 
      Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), 
      Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain.
FAU - Gualillo, Oreste
AU  - Gualillo O
AD  - SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in 
      Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), 
      Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140226
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Leptin)
RN  - 0 (Resistin)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
SB  - IM
MH  - Adipokines/*metabolism
MH  - Adiponectin/metabolism
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Humans
MH  - Leptin/metabolism
MH  - Metabolic Syndrome/complications/*metabolism
MH  - Nicotinamide Phosphoribosyltransferase/metabolism
MH  - Resistin/metabolism
MH  - Rheumatic Diseases/complications/*metabolism
PMC - PMC3987880
EDAT- 2014/04/18 06:00
MHDA- 2015/01/08 06:00
PMCR- 2014/02/26
CRDT- 2014/04/18 06:00
PHST- 2013/12/10 00:00 [received]
PHST- 2014/01/10 00:00 [revised]
PHST- 2014/01/10 00:00 [accepted]
PHST- 2014/04/18 06:00 [entrez]
PHST- 2014/04/18 06:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
PHST- 2014/02/26 00:00 [pmc-release]
AID - 10.1155/2014/343746 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:343746. doi: 10.1155/2014/343746. Epub 2014 Feb 26.