PMID- 24741606
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20211021
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - Transplant glomerulopathy: the interaction of HLA antibodies and endothelium.
PG  - 549315
LID - 10.1155/2014/549315 [doi]
LID - 549315
AB  - Transplant glomerulopathy (TG) is a major cause of chronic graft dysfunction 
      without effective therapy. Although the histological definition of TG is well 
      characterized, the pathophysiological pathways leading to TG development are 
      still poorly understood. Electron microscopy suggests an earlier appearance of TG 
      and suggests that endothelial cell injury is the first sign of the disease. The 
      pathogenic role of human leukocyte antigen (HLA) antibodies in endothelial cells 
      has been described in acute vascular and humoral rejection. However the 
      mechanisms and pathways of endothelial cell injury by HLA antibodies remain 
      unclear. Despite the description of different causes of the morphological lesion 
      of TG (hepatitis, thrombotic microangiopathy), the strong link between TG and 
      chronic antibody mediated rejection suggests a major role for HLA antibodies in 
      TG formation. In this review, we describe the effect of classes I or II 
      HLA-antibodies in TG and especially the implication of donor specific antibodies 
      (DSA). We update recent studies about endothelial cells and try to explain the 
      different signals and intracellular pathways involved in the progression of TG.
FAU - Hanf, William
AU  - Hanf W
AD  - Central Northern Adelaide Renal & Transplantation Service, Royal Adelaide 
      Hospital, Adelaide, SA 5000, Australia.
FAU - Bonder, Claudine S
AU  - Bonder CS
AD  - Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, SA 5000, Australia 
      ; Department of Medicine, University of Adelaide, Frome Road, Adelaide, SA 5000, 
      Australia ; Centre for Stem Cell Research, University of Adelaide, Frome Road, 
      Adelaide, SA 5000, Australia.
FAU - Coates, P Toby H
AU  - Coates PT
AD  - Central Northern Adelaide Renal & Transplantation Service, Royal Adelaide 
      Hospital, Adelaide, SA 5000, Australia ; Department of Medicine, University of 
      Adelaide, Frome Road, Adelaide, SA 5000, Australia ; Centre for Stem Cell 
      Research, University of Adelaide, Frome Road, Adelaide, SA 5000, Australia ; 
      Clinical and Experimental Transplantation Group, Royal Adelaide Hospital, North 
      Terrace, Adelaide, SA 5000, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140309
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Autoantibodies)
RN  - 0 (Complement C4)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibody Specificity/immunology
MH  - Autoantibodies/immunology
MH  - Complement C4/immunology
MH  - Endothelium/immunology/pathology
MH  - Glomerulonephritis/*immunology/*pathology/therapy
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Patient Outcome Assessment
MH  - Risk Factors
MH  - Transplants/*immunology/*pathology
PMC - PMC3987972
EDAT- 2014/04/18 06:00
MHDA- 2015/01/08 06:00
PMCR- 2014/03/09
CRDT- 2014/04/18 06:00
PHST- 2013/06/28 00:00 [received]
PHST- 2014/01/29 00:00 [revised]
PHST- 2014/01/30 00:00 [accepted]
PHST- 2014/04/18 06:00 [entrez]
PHST- 2014/04/18 06:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
PHST- 2014/03/09 00:00 [pmc-release]
AID - 10.1155/2014/549315 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:549315. doi: 10.1155/2014/549315. Epub 2014 Mar 9.