PMID- 24741608
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20211021
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - The many faces of human leukocyte antigen-G: relevance to the fate of pregnancy.
PG  - 591489
LID - 10.1155/2014/591489 [doi]
LID - 591489
AB  - Pregnancy is an immunological paradox, where fetal antigens encoded by 
      polymorphic genes inherited from the father do not provoke a maternal immune 
      response. The fetus is not rejected as it would be theorized according to 
      principles of tissue transplantation. A major contribution to fetal tolerance is 
      the human leukocyte antigen (HLA)-G, a nonclassical HLA protein displaying 
      limited polymorphism, restricted tissue distribution, and a unique alternative 
      splice pattern. HLA-G is primarily expressed in placenta and plays multifaceted 
      roles during pregnancy, both as a soluble and a membrane-bound molecule. Its 
      immunomodulatory functions involve interactions with different immune cells and 
      possibly regulation of cell migration during placental development. Recent 
      findings include HLA-G contributions from the father and the fetus itself. Much 
      effort has been put into clarifying the role of HLA-G during pregnancy and 
      pregnancy complications, such as preeclampsia, recurrent spontaneous abortions, 
      and subfertility or infertility. This review aims to clarify the multifunctional 
      role of HLA-G in pregnancy-related disorders by focusing on genetic variation, 
      differences in mRNA stability between HLA-G alleles, differences in HLA-G isoform 
      expression, and possible differences in functional activity. Furthermore, we 
      highlight important observations regarding HLA-G genetics and expression in 
      preeclampsia that future research should address.
FAU - Dahl, Mette
AU  - Dahl M
AUID- ORCID: 0000-0002-8036-3519
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Copenhagen University Hospital (Roskilde) and 
      Roskilde Hospital, 7-13 Kogevej, 4000 Roskilde, Denmark.
FAU - Djurisic, Snezana
AU  - Djurisic S
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Copenhagen University Hospital (Roskilde) and 
      Roskilde Hospital, 7-13 Kogevej, 4000 Roskilde, Denmark.
FAU - Hviid, Thomas Vauvert F
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Copenhagen University Hospital (Roskilde) and 
      Roskilde Hospital, 7-13 Kogevej, 4000 Roskilde, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140304
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Alleles
MH  - Alternative Splicing
MH  - Cell Membrane/metabolism
MH  - Female
MH  - Gene Expression Regulation
MH  - HLA-G Antigens/*physiology
MH  - Humans
MH  - Organ Specificity/genetics
MH  - Polymorphism, Genetic
MH  - Pre-Eclampsia/etiology
MH  - Pregnancy
MH  - Pregnancy Complications/etiology
MH  - *Pregnancy Outcome
MH  - Protein Transport
PMC - PMC3987982
EDAT- 2014/04/18 06:00
MHDA- 2015/01/08 06:00
PMCR- 2014/03/04
CRDT- 2014/04/18 06:00
PHST- 2013/12/09 00:00 [received]
PHST- 2014/01/17 00:00 [accepted]
PHST- 2014/04/18 06:00 [entrez]
PHST- 2014/04/18 06:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
PHST- 2014/03/04 00:00 [pmc-release]
AID - 10.1155/2014/591489 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:591489. doi: 10.1155/2014/591489. Epub 2014 Mar 4.