PMID- 24741627
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20240324
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - Type 2 diabetes, PUFAs, and vitamin D: their relation to inflammation.
PG  - 860703
LID - 10.1155/2014/860703 [doi]
LID - 860703
AB  - Chronic diseases have become one of the most important public health problems, 
      due to their high costs for treatment and prevention. Until now, researchers have 
      considered that the etiology of Type 2 diabetes mellitus (T2DM) is 
      multifactorial. Recently, the study of the innate immune system has offered an 
      explanation model of the pathogenesis of T2DM. On the other hand, there is 
      evidence about the beneficial effect of polyunsaturated fatty acids (PUFA) n-3 
      and n-6 in patients with chronic inflammatory diseases including diabetes. 
      Furthermore, high vitamin D plasmatic concentrations have been associated with 
      the best performance of pancreatic beta cells and the improving of this disease. In 
      conclusion, certain fatty acids in the adequate proportion as well as 
      25-hydroxivitamin D can modulate the inflammatory response in diabetic people, 
      modifying the evolution of this disease.
FAU - Guadarrama-Lopez, Ana L
AU  - Guadarrama-Lopez AL
AD  - Center for Research and Graduate Studies in Health Sciences, Faculty of Medicine, 
      Autonomous University of the State of Mexico, Paseo Tollocan Esquina, Jesus 
      Carranza, Col. Moderna de la Cruz Toluca, 50180 Mexico, MEX, Mexico.
FAU - Valdes-Ramos, Roxana
AU  - Valdes-Ramos R
AD  - Center for Research and Graduate Studies in Health Sciences, Faculty of Medicine, 
      Autonomous University of the State of Mexico, Paseo Tollocan Esquina, Jesus 
      Carranza, Col. Moderna de la Cruz Toluca, 50180 Mexico, MEX, Mexico.
FAU - Martinez-Carrillo, Beatriz E
AU  - Martinez-Carrillo BE
AD  - Center for Research and Graduate Studies in Health Sciences, Faculty of Medicine, 
      Autonomous University of the State of Mexico, Paseo Tollocan Esquina, Jesus 
      Carranza, Col. Moderna de la Cruz Toluca, 50180 Mexico, MEX, Mexico.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140224
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Adipokines)
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Incretins)
RN  - 0 (Insulin)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adipokines/blood/genetics
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/blood/genetics/*immunology/pathology
MH  - Fatty Acids, Omega-3/*blood
MH  - Fatty Acids, Omega-6/*blood
MH  - Gene Expression
MH  - Humans
MH  - Immunity, Innate
MH  - Incretins/blood/genetics
MH  - Inflammation/blood/genetics/immunology/pathology
MH  - Insulin/blood
MH  - Insulin-Secreting Cells/*immunology/metabolism/pathology
MH  - Vitamin D/*analogs & derivatives/blood
PMC - PMC3987931
EDAT- 2014/04/18 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/02/24
CRDT- 2014/04/18 06:00
PHST- 2013/10/31 00:00 [received]
PHST- 2014/01/08 00:00 [accepted]
PHST- 2014/04/18 06:00 [entrez]
PHST- 2014/04/18 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/02/24 00:00 [pmc-release]
AID - 10.1155/2014/860703 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:860703. doi: 10.1155/2014/860703. Epub 2014 Feb 24.