PMID- 24742099
OWN - NLM
STAT- MEDLINE
DCOM- 20140922
LR  - 20211021
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Print)
IS  - 1044-5498 (Linking)
VI  - 33
IP  - 8
DP  - 2014 Aug
TI  - Absence of association of interleukin-18 gene polymorphisms with primary immune 
      thrombocytopenia in a Chinese Han population.
PG  - 537-42
LID - 10.1089/dna.2013.2247 [doi]
AB  - Interleukin-18 (IL-18) is an inflammatory cytokine that plays an important role 
      in autoimmune disease by inducing interferon-gamma secretion. Considering the 
      abnormal serum concentration of IL-18 in primary immune thrombocytopenia (ITP) 
      patients and the regulated effect of IL-18 gene polymorphisms on its production, 
      the aim of this study was to investigate a possible association between the IL-18 
      promoter polymorphisms (-137 G/C and -607 C/A sites) and genetic susceptibility 
      to ITP in a Chinese Han population. A total of 181 ITP patients and 163 healthy 
      controls were included in this study; IL-18 gene promoter polymorphisms were 
      analyzed by a polymerase chain reaction with sequence-specific primers. No 
      significant differences in genotype (-607: chi(2)=0.307, p=0.858; -137: chi(2)=0.378, 
      p=0.828) and allele frequencies (-607: chi(2)=0.004, p=0.949; -137: chi(2)=0.307, 
      p=0.858) were found between total ITP patients and normal controls. We further 
      analyzed the association of IL-18 polymorphisms with clinical parameters of ITP 
      patients, including first onset age and clinical therapy response to 
      glucocorticoids, and no difference was revealed. In conclusion, IL-18 promoter 
      polymorphisms may not be associated with genetic susceptibility to ITP in a 
      Chinese Han population.
FAU - Li, Huiyuan
AU  - Li H
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College , Tianjin, People's Republic of China .
FAU - Xuan, Min
AU  - Xuan M
FAU - Xue, Feng
AU  - Xue F
FAU - Liu, Xiaofan
AU  - Liu X
FAU - Zhang, Donglei
AU  - Zhang D
FAU - Fu, Rongfeng
AU  - Fu R
FAU - Yang, Yanhui
AU  - Yang Y
FAU - Zhang, Xian
AU  - Zhang X
FAU - Yang, Renchi
AU  - Yang R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140417
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Infant
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Purpura, Thrombocytopenic, Idiopathic/*genetics
MH  - Risk
MH  - Sequence Analysis, DNA
MH  - Young Adult
PMC - PMC4117256
EDAT- 2014/04/20 06:00
MHDA- 2014/09/23 06:00
PMCR- 2015/08/01
CRDT- 2014/04/19 06:00
PHST- 2014/04/19 06:00 [entrez]
PHST- 2014/04/20 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - 10.1089/dna.2013.2247 [pii]
AID - 10.1089/dna.2013.2247 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2014 Aug;33(8):537-42. doi: 10.1089/dna.2013.2247. Epub 2014 Apr 
      17.