PMID- 24742208
OWN - NLM
STAT- MEDLINE
DCOM- 20141214
LR  - 20140418
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 36
IP  - 4
DP  - 2014 May
TI  - Mesenteric lymph duct ligation after hemorrhagic shock enhances the ATP level and 
      ATPase activity in rat kidneys.
PG  - 593-7
LID - 10.3109/0886022X.2014.882183 [doi]
AB  - BACKGROUND: Kidney injury commonly occurs following hemorrhagic shock. This study 
      aims to observe the effects of mesenteric lymph duct ligation (MLDL) on the 
      adenosine triphosphate (ATP) levels and the cell membrane adenosine 
      triphosphatase (ATPase) activity in the kidneys of rats subjected to hemorrhagic 
      shock. METHODS: Wistar rats were assigned into sham, shock, and ligation groups. 
      The hemorrhagic shock model was established in the shock and ligation groups, and 
      MLDL was performed in the ligation group after resuscitation. Renal homogenates 
      were prepared to determine the ATP and ATPase levels at 90 min after hemorrhage 
      and at 0, 1, 3, 6, 12, and 24 h after resuscitation. RESULTS: The ATP levels, and 
      the Na(+)-K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, and Ca(2+)-Mg(2+)-ATPase 
      activities in the renal tissue of the shock group were lower than those in the 
      sham group at the multiple time points. Furthermore, the corresponding values in 
      the ligation group were significantly higher than those in the shock group at 
      multiple time points. CONCLUSION: MLDL improves energy metabolism and enhances 
      the ATPase activity in the kidneys of hemorrhagic shock rats, along with other 
      mechanisms that alleviate renal injury after hemorrhagic shock.
FAU - Zhang, Li-Min
AU  - Zhang LM
AD  - Institute of Microcirculation, Hebei North University , Hebei , PR China and.
FAU - Jiang, Li-Jie
AU  - Jiang LJ
FAU - Zhao, Zi-Gang
AU  - Zhao ZG
FAU - Niu, Chun-Yu
AU  - Niu CY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
SB  - IM
MH  - Adenosine Triphosphatases/*metabolism
MH  - Adenosine Triphosphate/*metabolism
MH  - Animals
MH  - Cell Membrane/enzymology
MH  - Disease Models, Animal
MH  - Kidney/enzymology/*metabolism
MH  - Ligation
MH  - Lymphatic Vessels/*metabolism/surgery
MH  - Mesentery/*metabolism
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Shock, Hemorrhagic/*metabolism
EDAT- 2014/04/20 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/04/19 06:00
PHST- 2014/04/19 06:00 [entrez]
PHST- 2014/04/20 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 10.3109/0886022X.2014.882183 [doi]
PST - ppublish
SO  - Ren Fail. 2014 May;36(4):593-7. doi: 10.3109/0886022X.2014.882183.