PMID- 24742932
OWN - NLM
STAT- MEDLINE
DCOM- 20180116
LR  - 20180116
IS  - 0897-1900 (Print)
IS  - 0897-1900 (Linking)
VI  - 27
IP  - 3
DP  - 2014 Jun
TI  - Pregnancy-Related Venous Thromboembolism.
PG  - 243-52
LID - 10.1177/0897190014530425 [doi]
AB  - Pregnancy is associated with an increased risk of venous thromboembolism (VTE), 
      with a reported incidence ranging from 0.49 to 2 events per 1000 deliveries. Risk 
      factors include advanced maternal age, obesity, smoking, and cesarian section. 
      Women with a history of previous VTE are at a 4-fold higher risk of recurrent 
      thromboembolic events during subsequent pregnancies. Additionally, the presence 
      of concomitant thrombophilia, particularly factor V Leiden (homozygosity), 
      prothrombin gene mutation (homozygosity), or antiphospholipid syndrome (APS), 
      increases the risk of pregnancy-related VTE. Low-molecular-weight heparin (LMWH) 
      and unfractionated heparin (UFH) are the drugs of choice for anticoagulation 
      during pregnancy. LMWH is preferred due to ease of use and lower rates of adverse 
      events. Women with high thromboembolic risk particularly those with a family 
      history of VTE should receive antepartum thromboprophylaxis. Women with low 
      thromboembolic risk or previous VTE caused by a transient risk factor (ie, 
      provoked), who have no family history of VTE, may undergo antepartum 
      surveillance. Postpartum anticoagulation can be considered in women with both 
      high and low thromboembolic risk.
CI  - (c) The Author(s) 2014.
FAU - Armstrong, Emily M
AU  - Armstrong EM
AD  - Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, 
      Auburn, AL, USA Department of Internal Medicine, University of South Alabama, 
      Mobile, AL, USA ekm0010@auburn.edu.
FAU - Bellone, Jessica M
AU  - Bellone JM
AD  - Department of Pharmacy Practice, Concordia University Wisconsin School of 
      Pharmacy, Mequon, WI, USA.
FAU - Hornsby, Lori B
AU  - Hornsby LB
AD  - Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, 
      Auburn, AL, USA Midtown Medical Center, Outpatient Clinic, Columbus, GA, USA.
FAU - Treadway, Sarah
AU  - Treadway S
AD  - Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, 
      Auburn, AL, USA Department of Family Medicine, University of South Alabama, 
      Mobile, AL, USA.
FAU - Phillippe, Haley M
AU  - Phillippe HM
AD  - Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, 
      Auburn, AL, USA Family Medicine-Huntsville Campus, University of Alabama School 
      of Medicine, Huntsville, AL, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140417
PL  - United States
TA  - J Pharm Pract
JT  - Journal of pharmacy practice
JID - 8900945
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/adverse effects/*therapeutic use
MH  - Cesarean Section/adverse effects
MH  - Female
MH  - Heparin/adverse effects/therapeutic use
MH  - Heparin, Low-Molecular-Weight/adverse effects/therapeutic use
MH  - Humans
MH  - Maternal Age
MH  - Obesity/complications
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/drug therapy/*prevention & control
MH  - Risk Factors
MH  - Smoking/adverse effects
MH  - Venous Thromboembolism/drug therapy/*etiology/prevention & control
OTO - NOTNLM
OT  - acquired thrombophilia
OT  - inherited thrombophilia
OT  - pregnancy
OT  - prophylaxis
OT  - thrombophilia
EDAT- 2014/04/20 06:00
MHDA- 2014/04/20 06:01
CRDT- 2014/04/19 06:00
PHST- 2014/04/19 06:00 [entrez]
PHST- 2014/04/20 06:00 [pubmed]
PHST- 2014/04/20 06:01 [medline]
AID - 0897190014530425 [pii]
AID - 10.1177/0897190014530425 [doi]
PST - ppublish
SO  - J Pharm Pract. 2014 Jun;27(3):243-52. doi: 10.1177/0897190014530425. Epub 2014 
      Apr 17.