PMID- 24743216
OWN - NLM
STAT- MEDLINE
DCOM- 20150701
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 27
IP  - 11
DP  - 2014 Nov
TI  - Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and 
      cytogenetic features in adenoma and hepatocellular carcinoma portions of the 
      tumor.
PG  - 1499-1509
LID - 10.1038/modpathol.2014.50 [doi]
AB  - Well-differentiated hepatocellular carcinoma in non-cirrhotic liver can show 
      morphological features similar to hepatocellular adenoma. In rare instances, 
      hepatocellular carcinoma can arise in the setting of hepatocellular adenoma. This 
      study compares the immunohistochemical and cytogenetic features of the 
      hepatocellular adenoma-like and hepatocellular carcinoma portions of these 
      tumors. Immunohistochemistry for beta-catenin, glutamine synthetase, serum amyloid A 
      protein, glypican-3, and heat-shock protein 70 was done in 11 cases of 
      hepatocellular carcinoma arising in hepatocellular adenoma in non-cirrhotic 
      liver. Tumors with nuclear beta-catenin and/or diffuse glutamine synthetase were 
      considered beta-catenin activated. Fluorescence in situ hybridization (FISH) was 
      done in nine cases for gains of chromosomes 1, 8 and MYC. There were seven men 
      (33-75 years) and four women (29-65 years). Focal atypical morphological features 
      were seen in hepatocellular adenoma-like areas in 7 (64%) cases. Hepatocellular 
      adenoma-like areas showed features of inflammatory hepatocellular adenoma in 7 
      (64%) cases; 4 of these were also serum amyloid A-positive in the hepatocellular 
      carcinoma portion. beta-Catenin activation, heat-shock protein 70 positivity, and 
      chromosomal gains on FISH were seen in the hepatocellular adenoma portion in 55%, 
      40%, and 56% of cases, and 73%, 60%, and 78% of cases in the hepatocellular 
      carcinoma portion, respectively. In conclusion, the hepatocellular adenoma-like 
      portion of most cases of hepatocellular carcinoma arising in hepatocellular 
      adenoma shows features typically seen in hepatocellular carcinoma such as focal 
      morphological abnormalities, beta-catenin activation, heat-shock protein 70 
      expression, and chromosomal gains. Hepatocellular adenoma-like areas in these 
      tumors, especially in men and older women, may represent an extremely 
      well-differentiated variant of hepatocellular carcinoma, whereas the 
      morphologically recognizable hepatocellular carcinoma portion represents a 
      relatively higher grade component of the tumor.
FAU - Kakar, Sanjay
AU  - Kakar S
AD  - Department of Anatomic Pathology, University of California, San Francisco, CA, 
      USA.
AD  - Department of Pathology, Veteran Affairs Medical Center, San Francisco, CA, USA.
FAU - Grenert, James P
AU  - Grenert JP
AD  - Department of Anatomic Pathology, University of California, San Francisco, CA, 
      USA.
FAU - Paradis, Valerie
AU  - Paradis V
AD  - Department of Pathology, Beaujon Hospital, Clichy, France, Rush University, 
      Chicago, IL, USA.
FAU - Pote, Nicolas
AU  - Pote N
AD  - Department of Pathology, Beaujon Hospital, Clichy, France, Rush University, 
      Chicago, IL, USA.
FAU - Jakate, Shriram
AU  - Jakate S
AD  - Department of Pathology, Rush University, Chicago, IL, USA.
FAU - Ferrell, Linda D
AU  - Ferrell LD
AD  - Department of Anatomic Pathology, University of California, San Francisco, CA, 
      USA.
LA  - eng
GR  - P30 DK026743/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20140418
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (GPC3 protein, human)
RN  - 0 (Glypicans)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (Serum Amyloid A Protein)
RN  - 0 (beta Catenin)
RN  - EC 6.3.1.2 (Glutamate-Ammonia Ligase)
SB  - IM
MH  - Adenoma, Liver Cell/chemistry/*diagnosis/genetics/pathology
MH  - Adult
MH  - Aged
MH  - *Biomarkers, Tumor/analysis/genetics
MH  - Carcinoma, Hepatocellular/chemistry/*diagnosis/genetics/pathology
MH  - Cell Differentiation
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 8
MH  - Female
MH  - Glutamate-Ammonia Ligase/analysis
MH  - Glypicans/analysis
MH  - HSP70 Heat-Shock Proteins/analysis
MH  - Humans
MH  - *Immunohistochemistry
MH  - *In Situ Hybridization, Fluorescence
MH  - Liver Neoplasms/chemistry/*diagnosis/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasms, Complex and Mixed/chemistry/*diagnosis/genetics/pathology
MH  - Predictive Value of Tests
MH  - Proto-Oncogene Proteins c-myc/genetics
MH  - Serum Amyloid A Protein/analysis
MH  - beta Catenin/analysis
PMC - PMC4803443
MID - NIHMS767835
EDAT- 2014/04/20 06:00
MHDA- 2015/07/02 06:00
PMCR- 2016/03/22
CRDT- 2014/04/19 06:00
PHST- 2013/09/27 00:00 [received]
PHST- 2014/02/24 00:00 [revised]
PHST- 2014/02/25 00:00 [accepted]
PHST- 2014/04/19 06:00 [entrez]
PHST- 2014/04/20 06:00 [pubmed]
PHST- 2015/07/02 06:00 [medline]
PHST- 2016/03/22 00:00 [pmc-release]
AID - S0893-3952(22)03541-4 [pii]
AID - 10.1038/modpathol.2014.50 [doi]
PST - ppublish
SO  - Mod Pathol. 2014 Nov;27(11):1499-1509. doi: 10.1038/modpathol.2014.50. Epub 2014 
      Apr 18.