PMID- 24743517
OWN - NLM
STAT- MEDLINE
DCOM- 20150218
LR  - 20140807
IS  - 1460-2180 (Electronic)
IS  - 0143-3334 (Linking)
VI  - 35
IP  - 8
DP  - 2014 Aug
TI  - Systematic investigation of contribution of genetic variation in the HLA-DP 
      region to cervical cancer susceptibility.
PG  - 1765-9
LID - 10.1093/carcin/bgu096 [doi]
AB  - Compared with the other human leukocyte antigen (HLA) genes, few studies have 
      evaluated the role of HLA-DP genes in cervical cancer pathogenesis. A recent 
      genome-wide association study (GWAS) in the Swedish population has identified a 
      susceptibility locus for cervical cancer within the HLA-DP region. To further 
      study this locus, we imputed classic HLA alleles using single-nucleotide 
      polymorphism (SNP) data and analysed 449 genotyped and 3066 imputed SNPs in 1034 
      cervical cancer patients and 3948 controls. We confirmed that the strongest 
      signal came from a SNP located at HLA-DPB2 [rs3117027, odds ratio (OR) = 1.29, 
      95% confidence interval (CI) = 1.16-1.43, P = 1.9 x 10(-6) for A allele] and that 
      this effect is not driven by associations with classic HLA alleles. In silico 
      analysis further revealed that this SNP is highly correlated with rs3129294 (D' = 
      1, r(2) = 0.95 in controls), which may have a putative regulatory function. We 
      also identified an independent association at DPB1*0402, which conferred 
      decreased risk of cervical cancer (OR = 0.75, 95% CI = 0.63-0.89, P = 7.0 x 
      10(-4)) and is independent of previously described associations with HLA-B*0702, 
      DRB1*1501-DQB1*0602, and DRB1*1301-DQA1*0103-DQB1*0603. No association was found 
      with the two SNPs (rs4282438 or rs9277952) that were recently identified within 
      the HLA-DP region in a cervical cancer GWAS in the Chinese population. Our study 
      provides the first systematic investigation of the association of genetic 
      variants in the HLA-DP region with cervical cancer susceptibility and provides 
      further insight into the contribution of polymorphisms in the HLA-DP region to 
      risk of cervical cancer.
CI  - (c) The Author 2014. Published by Oxford University Press. All rights reserved. For 
      Permissions, please email: journals.permissions@oup.com.
FAU - Chen, Dan
AU  - Chen D
AD  - Department of Immunology, Genetics and Pathology, SciLifeLab Uppsala, Biomedical 
      Center, Uppsala University, 75108 Uppsala, Sweden dan.chen@igp.uu.se 
      simpledandan@gmail.com.
FAU - Gyllensten, Ulf
AU  - Gyllensten U
AD  - Department of Immunology, Genetics and Pathology, SciLifeLab Uppsala, Biomedical 
      Center, Uppsala University, 75108 Uppsala, Sweden.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140417
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (HLA-DP Antigens)
SB  - IM
MH  - Carcinoma in Situ/epidemiology/*genetics/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - HLA-DP Antigens/*genetics
MH  - Humans
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prognosis
MH  - Sweden/epidemiology
MH  - Twin Studies as Topic
MH  - Uterine Cervical Neoplasms/epidemiology/*genetics/pathology
EDAT- 2014/04/20 06:00
MHDA- 2015/02/19 06:00
CRDT- 2014/04/19 06:00
PHST- 2014/04/19 06:00 [entrez]
PHST- 2014/04/20 06:00 [pubmed]
PHST- 2015/02/19 06:00 [medline]
AID - bgu096 [pii]
AID - 10.1093/carcin/bgu096 [doi]
PST - ppublish
SO  - Carcinogenesis. 2014 Aug;35(8):1765-9. doi: 10.1093/carcin/bgu096. Epub 2014 Apr 
      17.