PMID- 24743889
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 4
DP  - 2014 Apr 16
TI  - The role of pericytes in neurovascular unit remodeling in brain disorders.
PG  - 6453-74
LID - 10.3390/ijms15046453 [doi]
AB  - Neurons are extremely vulnerable cells that tightly rely on the brain's highly 
      dynamic and complex vascular network that assures an accurate and adequate 
      distribution of nutrients and oxygen. The neurovascular unit (NVU) couples 
      neuronal activity to vascular function, controls brain homeostasis, and maintains 
      an optimal brain microenvironment adequate for neuronal survival by adjusting 
      blood-brain barrier (BBB) parameters based on brain needs. The NVU is a 
      heterogeneous structure constituted by different cell types that includes 
      pericytes. Pericytes are localized at the abluminal side of brain microvessels 
      and contribute to NVU function. Pericytes play essential roles in the development 
      and maturation of the neurovascular system during embryogenesis and stability 
      during adulthood. Initially, pericytes were described as contractile cells 
      involved in controlling neurovascular tone. However, recent reports have shown 
      that pericytes dynamically respond to stress induced by injury upon brain 
      diseases, by chemically and physically communicating with neighboring cells, by 
      their immune properties and by their potential pluripotent nature within the 
      neurovascular niche. As such, in this paper, we would like to review the role of 
      pericytes in NVU remodeling, and their potential as targets for NVU repair 
      strategies and consequently neuroprotection in two pathophysiologically distinct 
      brain disorders: ischemic stroke and Alzheimer's disease (AD).
FAU - ElAli, Ayman
AU  - ElAli A
AD  - Neuroscience Laboratory, CHU de Quebec Research Center and Department of 
      Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier boul., 
      Quebec City, QC G1V 4G2, Canada. ayman.el-ali@crchuq.ulaval.ca.
FAU - Theriault, Peter
AU  - Theriault P
AD  - Neuroscience Laboratory, CHU de Quebec Research Center and Department of 
      Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier boul., 
      Quebec City, QC G1V 4G2, Canada. peter.theriault@crchuq.ulaval.ca.
FAU - Rivest, Serge
AU  - Rivest S
AD  - Neuroscience Laboratory, CHU de Quebec Research Center and Department of 
      Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier boul., 
      Quebec City, QC G1V 4G2, Canada. serge.rivest@crchul.ulaval.ca.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140416
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Extracellular Matrix Proteins)
SB  - IM
MH  - ATP-Binding Cassette Transporters/metabolism
MH  - Blood-Brain Barrier/metabolism
MH  - Brain Diseases/*metabolism/pathology
MH  - Extracellular Matrix Proteins/metabolism
MH  - Humans
MH  - Neurons/metabolism
MH  - Pericytes/cytology/*metabolism
MH  - Signal Transduction
PMC - PMC4013640
EDAT- 2014/04/20 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/04/01
CRDT- 2014/04/19 06:00
PHST- 2014/02/17 00:00 [received]
PHST- 2014/04/01 00:00 [revised]
PHST- 2014/04/08 00:00 [accepted]
PHST- 2014/04/19 06:00 [entrez]
PHST- 2014/04/20 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - ijms15046453 [pii]
AID - ijms-15-06453 [pii]
AID - 10.3390/ijms15046453 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 Apr 16;15(4):6453-74. doi: 10.3390/ijms15046453.