PMID- 24744464
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140418
LR  - 20211021
IS  - 0860-021X (Print)
IS  - 2083-1862 (Electronic)
IS  - 0860-021X (Linking)
VI  - 30
IP  - 1
DP  - 2013 Mar
TI  - Endurance exercise training and diferuloyl methane supplement: changes in 
      neurotrophic factor and oxidative stress induced by lead in rat brain.
PG  - 41-6
LID - 10.5604/20831862.1029820 [doi]
AB  - Lead is a highly neurotoxic agent that particularly affects the developing 
      central nervous system. In the current study we investigated the neuroprotective 
      effects of exercise training and/or diferuloyl methane (DM) supplement, which is 
      known as curcumin, on lead acetate-induced neurotoxicity in the rat hippocampus. 
      Sixty rats were randomly divided into six groups: 1) lead acetate, 2) DM 
      supplement, 3) endurance training, 4) training+ DM supplement, 5) sham and 6) 
      base. The rats in the training groups performed treadmill running consisting of 
      15 to 22 m . min(-1) for 25 to 64 min, 5 times a week for 8 weeks. All groups 
      except sham received lead acetate (20 mg . kg(-1)), whereas the sham group 
      received DM solvent. In addition, the DM and training + DM groups received DM 
      solution (30 mg . kg(-1)) intraperitoneally. Chronic administration of lead 
      acetate resulted in a significant increase in the malondialdehyde (MDA) in 
      plasma, but not in the hippocampus. In addition, it led to significantly 
      decreased brain-derived neurotrophic factor (BDNF) in the hippocampus and total 
      antioxidant capacity (TAC) levels, as compared to the sham group. Treadmill 
      running, DM supplementation, or both resulted in a significant decrease in MDA 
      levels and significantly increased BDNF and TAC levels, as compared to the lead 
      acetate group. These results provide a rationale for an inhibitory role of DM 
      supplement and regular exercise in the attenuation of lead-induced neurotoxicity.
FAU - Dabidi, Roshan V
AU  - Dabidi RV
AD  - College of Physical Education and Sport Sciences, Department of Sport Physiology, 
      University of Mazandaran, Babolsar, Iran.
FAU - Hosseinzadeh, S
AU  - Hosseinzadeh S
AD  - Babol University of Medical Sciences, Babol, Iran.
FAU - Mahjoub, S
AU  - Mahjoub S
AD  - Fatemeh Zahra Infertility and Reproductive health Research Center, Babol 
      University of Medical Sciences, Babol, Iran ; Department of Biochemistry and 
      Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, 
      Iran.
FAU - Hosseinzadeh, M
AU  - Hosseinzadeh M
AD  - Center for Sensory-Motor Interaction (SMI), Department of Health Science and 
      Technology, Faculty of Medicine, Aalborg University, Fredrik Bajers vej 7D-3, DK 
      9220 Aalborg, Denmark.
FAU - Myers, J
AU  - Myers J
AD  - Cardiology Division, VA Palo Alto Health Care System, Stanford University, Palo 
      Alto, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20130121
PL  - Poland
TA  - Biol Sport
JT  - Biology of sport
JID - 8700872
PMC - PMC3944559
OTO - NOTNLM
OT  - BDNF
OT  - diferuloyl methane supplement
OT  - endurance exercise
OT  - lead
OT  - oxidative stress
EDAT- 2014/04/20 06:00
MHDA- 2014/04/20 06:01
PMCR- 2013/03/01
CRDT- 2014/04/19 06:00
PHST- 2012/08/17 00:00 [accepted]
PHST- 2014/04/19 06:00 [entrez]
PHST- 2014/04/20 06:00 [pubmed]
PHST- 2014/04/20 06:01 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - 1029820 [pii]
AID - 10.5604/20831862.1029820 [doi]
PST - ppublish
SO  - Biol Sport. 2013 Mar;30(1):41-6. doi: 10.5604/20831862.1029820. Epub 2013 Jan 21.