PMID- 24744866
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140418
LR  - 20211021
IS  - 2051-817X (Print)
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 1
IP  - 7
DP  - 2013 Dec 1
TI  - Evidence for a prosurvival role of alpha-7 nicotinic acetylcholine receptor in 
      alternatively (M2)-activated macrophages.
PG  - e00189
LID - 10.1002/phy2.189 [doi]
LID - e00189
AB  - Recent observations in endothelial cells and macrophages indicate that nicotinic 
      acetylcholine receptors (nAChRs) are potential novel players in mechanisms linked 
      to atherogenesis. In macrophages, alpha7nAChR mediates anti-inflammatory actions and 
      contributes to regulation of cholesterol flux and phagocytosis. Considering that 
      macrophage apoptosis is a key process throughout all stages of atherosclerotic 
      lesion development, in the present study, we examined for the first time the 
      impact of alpha7nAChR expression and function in macrophage survival and apoptosis 
      using in vitro polarized (M1 and M2) bone marrow-derived macrophages (BMDMs) from 
      wild-type and alpha7nAChR knockout mice. Our findings show that stimulation of 
      alpha7nAChR results in activation of the STAT3 prosurvival pathway and protection of 
      macrophages from endoplasmic reticulum (ER) stress-induced apoptosis. These 
      actions are rather selective for M2 BMDMs and are associated to activation of the 
      JAK2/STAT3 axis. Remarkably, these effects are completely lost in M2 macrophages 
      lacking alpha7nAChR.
FAU - Lee, Robert H
AU  - Lee RH
AD  - Department of Physiology and Pharmacology, Center for Diabetes and Endocrine 
      Research, University of Toledo College of Medicine, Health Science Campus, 3000 
      Arlington Av, Toledo, 43614, Ohio, USA.
FAU - Vazquez, Guillermo
AU  - Vazquez G
AD  - Department of Physiology and Pharmacology, Center for Diabetes and Endocrine 
      Research, University of Toledo College of Medicine, Health Science Campus, 3000 
      Arlington Av, Toledo, 43614, Ohio, USA.
LA  - eng
GR  - R01 HL111877/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20131226
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
PMC - PMC3970735
OTO - NOTNLM
OT  - Macrophage polarization
OT  - macrophage survival
OT  - alpha7 nicotinic acetylcholine receptor
EDAT- 2014/04/20 06:00
MHDA- 2014/04/20 06:01
PMCR- 2013/12/26
CRDT- 2014/04/19 06:00
PHST- 2013/11/21 00:00 [received]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2014/04/19 06:00 [entrez]
PHST- 2014/04/20 06:00 [pubmed]
PHST- 2014/04/20 06:01 [medline]
PHST- 2013/12/26 00:00 [pmc-release]
AID - phy2189 [pii]
AID - 10.1002/phy2.189 [doi]
PST - epublish
SO  - Physiol Rep. 2013 Dec 26;1(7):e00189. doi: 10.1002/phy2.189. eCollection 2013 Dec 
      1.