PMID- 2474506
OWN - NLM
STAT- MEDLINE
DCOM- 19890915
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 57
IP  - 9
DP  - 1989 Sep
TI  - Francisella tularensis-specific T-cell clones are human leukocyte antigen class 
      II restricted, secrete interleukin-2 and gamma interferon, and induce 
      immunoglobulin production.
PG  - 2906-8
AB  - T-cell clones (TLC) were established from a Francisella tularensis-vaccinated 
      subject in order to study the cells responsive for cell-mediated immunity against 
      F. tularensis. All the clones were human leukocyte antigen (HLA) class II 
      restricted to one of the HLA-DR specificities of the original donor. The TLC 
      cells were CD4+ and produced interleukin-2 and gamma interferon after stimulation 
      with specific antigen. Seven of the eight clones tested assisted in the 
      production of immunoglobulin G (IgG), IgA, and IgM antibodies.
FAU - Surcel, H M
AU  - Surcel HM
AD  - National Public Health Institute, University of Oulu, Finland.
FAU - Ilonen, J
AU  - Ilonen J
FAU - Poikonen, K
AU  - Poikonen K
FAU - Herva, E
AU  - Herva E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Epitopes)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulins)
RN  - 0 (Interleukin-2)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Clone Cells/immunology/metabolism/microbiology
MH  - Epitopes/immunology
MH  - Francisella tularensis/*immunology
MH  - HLA-DQ Antigens/immunology
MH  - HLA-DR Antigens/immunology
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Immunoglobulins/*biosynthesis
MH  - Interferon-gamma/*biosynthesis
MH  - Interleukin-2/*biosynthesis
MH  - T-Lymphocytes/*immunology/metabolism/microbiology
PMC - PMC313546
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
PMCR- 1989/09/01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
PHST- 1989/09/01 00:00 [pmc-release]
AID - 10.1128/iai.57.9.2906-2908.1989 [doi]
PST - ppublish
SO  - Infect Immun. 1989 Sep;57(9):2906-8. doi: 10.1128/iai.57.9.2906-2908.1989.