PMID- 24745151
OWN - NLM
STAT- MEDLINE
DCOM- 20140515
LR  - 20191112
IS  - 0015-5497 (Print)
IS  - 0015-5497 (Linking)
VI  - 62
IP  - 1
DP  - 2014
TI  - Lack of TCRalphabeta+ CD8+ and TCRgammadelta+ lymphocytes ameliorates LPS induced 
      orchitis in mice--preliminary histological observations.
PG  - 67-71
AB  - The inflammation of the reproductive system can affect reproduction causing 
      partial or complete infertility. It is well known that lipopolysaccharide (LPS) 
      triggers an inflammatory response in the whole organism, including 
      immunologically privileged organs, e.g. the testicles. Adult male TCRalpha-/-, 
      TCRdelta-/-, CD1d-/- and beta2m-/- on B10.PL (H-2(u)) and B10.PL control mice 
      were intraperitonealy (i.p.) injected with lipopolysaccharide (LPS). The animals 
      were killed 24h and 10 days post LPS treatment and their gonads were prepared for 
      microscopic examination. Histological changes in the testes after LPS injection 
      were found only in control B10PL and CD1d-/- mice. The experiments revealed 
      disturbances in Leydig's glands structure, blood vessel dilatation in the 
      interstitial tissue as well as degeneration of seminal tubule epithelium, 
      disruption ofspermatogenesis and subsequent decrease of sperm cell number in the 
      tubule lumen. These changes were noticed mainly 10 days after LPS treatment. Lack 
      of either TCRalphabeta+ CD8+ or TCRgammadelta+ lymphocytes diminishes the 
      response of testicular macrophages to LPS whereas the absence of CD1d-dependent 
      NKT cells does not affect macrophage reactivity.
FAU - Sliwa, Leopold
AU  - Sliwa L
FAU - Macura, Barbara
AU  - Macura B
FAU - Majewska-Szczepanik, Monika
AU  - Majewska-Szczepanik M
FAU - Szczepanik, Marian
AU  - Szczepanik M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Folia Biol (Krakow)
JT  - Folia biologica
JID - 2984758R
RN  - 0 (CD8 Antigens)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
SB  - IM
MH  - Animals
MH  - CD8 Antigens/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Lipopolysaccharides
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Orchitis/*chemically induced
MH  - Receptors, Antigen, T-Cell, alpha-beta/genetics/*metabolism
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics/*metabolism
MH  - T-Lymphocyte Subsets/*physiology
MH  - Testis/drug effects/metabolism/pathology
EDAT- 2014/04/22 06:00
MHDA- 2014/05/16 06:00
CRDT- 2014/04/22 06:00
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2014/05/16 06:00 [medline]
AID - 10.3409/fb62_1.67 [doi]
PST - ppublish
SO  - Folia Biol (Krakow). 2014;62(1):67-71. doi: 10.3409/fb62_1.67.