PMID- 24745471
OWN - NLM
STAT- MEDLINE
DCOM- 20141205
LR  - 20211021
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 218
IP  - 1-2
DP  - 2014 Aug 15
TI  - The BDNF Val66Met polymorphism does not moderate the effect of self-reported 
      physical activity on depressive symptoms in midlife.
PG  - 93-7
LID - S0165-1781(14)00255-8 [pii]
LID - 10.1016/j.psychres.2014.03.028 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide 
      polymorphism may be associated with clinical and subsyndromal depression, but 
      physical activity improves mood and increases BDNF expression. The aim of the 
      study was to examine whether the BDNF polymorphism moderates an effect of 
      physical activity on depressive symptoms. BDNF genotype, physical activity 
      measured by the Paffenbarger Questionnaire, and depressive symptoms using the 
      Center for Epidemiology Depression Scale (CES-D) were collected on 1072 
      participants (mean age=44). Multiple linear regression was used to examine the 
      association between BDNF genotype, physical activity, and depressive symptoms. 
      After adjusting for family income, age, and education, depressive symptoms were 
      higher in Met carriers compared to Val homozygotes (p=0.03), but this was only 
      significant in men. Physical activity was associated with fewer depressive 
      symptoms, but only in women (p=0.01). BDNF genotype did not moderate the effect 
      of physical activity on depressive symptoms (p=0.94). In midlife, the BDNF 
      Val66Met polymorphism neither attenuates nor magnifies the effect of physical 
      activity on depressive symptoms.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Gujral, Swathi
AU  - Gujral S
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center 
      for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Manuck, Stephen B
AU  - Manuck SB
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center 
      for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Ferrell, Robert E
AU  - Ferrell RE
AD  - Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Flory, Janine D
AU  - Flory JD
AD  - Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
FAU - Erickson, Kirk I
AU  - Erickson KI
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center 
      for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA. 
      Electronic address: kiericks@pitt.edu.
LA  - eng
GR  - P01 HL040962/HL/NHLBI NIH HHS/United States
GR  - P01HL040962/HL/NHLBI NIH HHS/United States
GR  - R01HL065137/HL/NHLBI NIH HHS/United States
GR  - R01 DK095172/DK/NIDDK NIH HHS/United States
GR  - R01 HL065137/HL/NHLBI NIH HHS/United States
GR  - R01DK095172/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140408
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - *Affect
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depression/*genetics/psychology
MH  - Exercise/physiology/*psychology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/physiology
MH  - *Polymorphism, Single Nucleotide
MH  - Psychiatric Status Rating Scales
MH  - Self Report
MH  - Surveys and Questionnaires
PMC - PMC4059542
MID - NIHMS584443
OTO - NOTNLM
OT  - BDNF polymorphism
OT  - Depression
OT  - Exercise
COIS- Disclosures and Declarations All authors declare no conflicts of interest.
EDAT- 2014/04/22 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/08/15
CRDT- 2014/04/22 06:00
PHST- 2013/12/05 00:00 [received]
PHST- 2014/03/05 00:00 [revised]
PHST- 2014/03/24 00:00 [accepted]
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/08/15 00:00 [pmc-release]
AID - S0165-1781(14)00255-8 [pii]
AID - 10.1016/j.psychres.2014.03.028 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 Aug 15;218(1-2):93-7. doi: 10.1016/j.psychres.2014.03.028. 
      Epub 2014 Apr 8.