PMID- 24745616
OWN - NLM
STAT- MEDLINE
DCOM- 20140821
LR  - 20230202
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 45
IP  - 7
DP  - 2014 Jul
TI  - Differential expression of GATA-3 in urothelial carcinoma variants.
PG  - 1466-72
LID - S0046-8177(14)00109-9 [pii]
LID - 10.1016/j.humpath.2014.02.023 [doi]
AB  - GATA binding protein 3 (GATA-3) is a novel immunohistochemical marker for 
      urothelial carcinoma (UC); however, few studies have investigated GATA-3's role 
      as a marker for UC variants. We used immunohistochemistry to assess GATA-3 
      expression in different UC variants, including micropapillary (n = 46), 
      sarcomatoid (n = 43), small cell carcinoma (n = 22), and plasmacytoid (n = 16) 
      variants, and we also compared GATA-3 expression in conventional bladder UC (n = 
      103) to that in squamous cell carcinoma (n = 14). GATA-3 expression was present 
      in 70% (72/103) of conventional bladder UCs and highly concordant between matched 
      primary and metastatic UCs. The GATA-3 expression levels of the micropapillary 
      variants (57%; 26/46) and plasmacytoid variants (44%; 7/16) were not 
      significantly different from that of conventional UC. However, the GATA-3 
      expression levels of the sarcomatoid variants (16%; 7/43) and small cell 
      carcinoma variants (5%; 1/22), which only weakly expressed the protein, were 
      significantly lower than that of conventional UC (P < .001). Only 7% of squamous 
      cell carcinomas (1/14) expressed GATA-3, and it was also significantly lower than 
      that of conventional UC (P < .001). GATA-3 expression was not significantly 
      associated with tumor stage or patients' clinical outcomes. In conclusion, GATA-3 
      expression differed among UC variants. GATA-3 is a useful marker for confirming 
      the urothelial origin of micropapillary and plasmacytoid UC variants but not that 
      of sarcomatoid or small cell carcinoma variants. GATA-3 can also be used in 
      differentiating UC from squamous cell carcinoma.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Liang, Yu
AU  - Liang Y
AD  - Department of Pathology, The University of Texas MD Anderson Cancer Center, 
      Houston, TX 77030, USA.
FAU - Heitzman, Joseph
AU  - Heitzman J
AD  - Department of Pathology, The University of Texas MD Anderson Cancer Center, 
      Houston, TX 77030, USA.
FAU - Kamat, Ashish M
AU  - Kamat AM
AD  - Department of Urology, The University of Texas MD Anderson Cancer Center, 
      Houston, TX 77030, USA.
FAU - Dinney, Colin P
AU  - Dinney CP
AD  - Department of Urology, The University of Texas MD Anderson Cancer Center, 
      Houston, TX 77030, USA.
FAU - Czerniak, Bogdan
AU  - Czerniak B
AD  - Department of Pathology, The University of Texas MD Anderson Cancer Center, 
      Houston, TX 77030, USA.
FAU - Guo, Charles C
AU  - Guo CC
AD  - Department of Pathology, The University of Texas MD Anderson Cancer Center, 
      Houston, TX 77030, USA. Electronic address: ccguo@mdanderson.org.
LA  - eng
GR  - CA16672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140315
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*diagnosis/metabolism/pathology
MH  - Carcinoma, Transitional Cell/*diagnosis/metabolism/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - GATA3 Transcription Factor/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Urinary Bladder Neoplasms/*diagnosis/metabolism/pathology
MH  - Urothelium/*metabolism/pathology
OTO - NOTNLM
OT  - GATA-3
OT  - Immunohistochemistry
OT  - Urothelial carcinoma variants
EDAT- 2014/04/22 06:00
MHDA- 2014/08/22 06:00
CRDT- 2014/04/22 06:00
PHST- 2013/12/10 00:00 [received]
PHST- 2014/02/24 00:00 [revised]
PHST- 2014/02/28 00:00 [accepted]
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2014/08/22 06:00 [medline]
AID - S0046-8177(14)00109-9 [pii]
AID - 10.1016/j.humpath.2014.02.023 [doi]
PST - ppublish
SO  - Hum Pathol. 2014 Jul;45(7):1466-72. doi: 10.1016/j.humpath.2014.02.023. Epub 2014 
      Mar 15.