PMID- 24745719
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20140512
IS  - 1879-2472 (Electronic)
IS  - 0049-3848 (Linking)
VI  - 133
IP  - 6
DP  - 2014 Jun
TI  - Unprovoked proximal venous thrombosis is associated with an increased risk of 
      asymptomatic pulmonary embolism.
PG  - 1011-5
LID - S0049-3848(14)00158-3 [pii]
LID - 10.1016/j.thromres.2014.02.033 [doi]
AB  - INTRODUCTION: Pulmonary embolism (PE) is common in patients with deep venous 
      thrombosis (DVT). The outcome of DVT with concomitant symptomatic PE is worse 
      than the outcome of isolated DVT. The risk factors for DVT and simultaneous 
      asymptomatic PE have not been systematically studied yet. AIM: To evaluate the 
      frequency and risk factors for asymptomatic PE in patients with DVT. 
      PATIENTS/METHODS: In 155 consecutive patients with a first episode of DVT and no 
      PE symptoms, a ventilation-perfusion lung scan was performed. Body mass index 
      (BMI) and waist-to-hip ratio (WHR) were calculated and concentrations of D-dimer, 
      high-sensitivity CRP (hsCRP), tissue plasminogen activator (t-PA) and troponin 
      were measured. Laboratory tests for thrombophilia were performed. RESULTS: 
      Asymptomatic PE was present in 36% of patients. No differences in gender, age, 
      BMI and WHR were found between the patients with and without PE. PE was more 
      common in patients with proximal DVT than in those with distal DVT (42% vs. 17%, 
      p<0.01), and in patients with unprovoked DVT compared to patients with provoked 
      DVT (51% vs. 28%, p<0.01). The risk of silent PE was the highest in patients with 
      unprovoked proximal DVT (OR, 6.9; 95% CI, 2.3-21.0). Patients with asymptomatic 
      PE had significantly higher values of D-dimer, hsCRP, t-PA and troponin than 
      patients with isolated DVT. CONCLUSIONS: Asymptomatic PE affected more than one 
      third of patients with a first DVT. Unprovoked proximal DVT is the most important 
      risk factor for the occurrence of silent PE.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Boc, Anja
AU  - Boc A
AD  - Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia; 
      Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Slovenia.
FAU - Vene, Nina
AU  - Vene N
AD  - Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia.
FAU - Stalc, Monika
AU  - Stalc M
AD  - Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia.
FAU - Kosmelj, Katarina
AU  - Kosmelj K
AD  - Biotechnical Faculty, University of Ljubljana, Slovenia.
FAU - Mavri, Alenka
AU  - Mavri A
AD  - Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia. 
      Electronic address: alenka.mavri@kclj.si.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140319
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Embolism/*etiology
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Venous Thrombosis/*complications
OTO - NOTNLM
OT  - Deep venous thrombosis
OT  - Incidence
OT  - Pulmonary embolism
OT  - Risk factors
EDAT- 2014/04/22 06:00
MHDA- 2015/01/16 06:00
CRDT- 2014/04/22 06:00
PHST- 2014/01/02 00:00 [received]
PHST- 2014/02/02 00:00 [revised]
PHST- 2014/02/14 00:00 [accepted]
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
AID - S0049-3848(14)00158-3 [pii]
AID - 10.1016/j.thromres.2014.02.033 [doi]
PST - ppublish
SO  - Thromb Res. 2014 Jun;133(6):1011-5. doi: 10.1016/j.thromres.2014.02.033. Epub 
      2014 Mar 19.