PMID- 24746014
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20181202
IS  - 1744-7593 (Electronic)
IS  - 1742-5247 (Linking)
VI  - 11
IP  - 6
DP  - 2014 Jun
TI  - Drug delivery/imaging multifunctionality of mesoporous silica-based composite 
      nanostructures.
PG  - 917-30
LID - 10.1517/17425247.2014.908181 [doi]
AB  - INTRODUCTION: Biocompatible mesoporous silica nanoparticles (MSNs) are regarded 
      as one of the most promising inorganic drug delivery systems (DDSs) to 
      concurrently enhance the therapeutic efficiency and mitigate the side effects of 
      anticancer drugs. Elaborately combining multicomponents with MSNs will endow them 
      with specific functionalities for cancer therapy and diagnosis, such as targeted 
      drug delivery, intelligent on-demand drug releasing, synergistic therapy, 
      diagnostic imaging and so on. AREAS COVERED: This review discusses the 
      state-of-the-art potential obstacles and further perspectives of the chemical 
      design/synthesis, in vitro/in vivo pharmaceutical evaluations and potential 
      clinical translations of multifunctional mesoporous silica-based nanomaterials 
      for biotechnological and biomedical applications, especially against cancer. 
      These topics cover the years from 2001 to 2013. EXPERT OPINION: Through the 
      comprehensive evaluations of the biosafety and pharmaceutical efficiency, 
      elaborately designed/fabricated mesoporous silica-based composite nanoparticles 
      show great potentials in clinical applications for efficient diagnostic imaging 
      and chemotherapy of cancer.
FAU - Chen, Yu
AU  - Chen Y
AD  - Shanghai Institute of Ceramics, Chinese Academy of Sciences, State Key Laboratory 
      of High Performance Ceramics and Superfine Microstructures , Shanghai, 200050 , 
      PR China +0086 21 52413122 ; +0086 21 64250740 ; jlshi@sunm.shcnc.ac.cn , 
      hrchen@mail.sic.ac.cn.
FAU - Chen, Hangrong
AU  - Chen H
FAU - Shi, Jianlin
AU  - Shi J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140419
PL  - England
TA  - Expert Opin Drug Deliv
JT  - Expert opinion on drug delivery
JID - 101228421
RN  - 0 (Antineoplastic Agents)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage/chemistry/therapeutic use
MH  - *Diagnostic Imaging
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Nanoparticles/chemistry/therapeutic use
MH  - Nanostructures/*chemistry
MH  - Neoplasms/drug therapy
MH  - Porosity
MH  - Silicon Dioxide/*chemistry
OTO - NOTNLM
OT  - cancer
OT  - drug delivery
OT  - mesoporous silica
OT  - nanomedicine
OT  - theranostic
EDAT- 2014/04/22 06:00
MHDA- 2014/07/25 06:00
CRDT- 2014/04/22 06:00
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
AID - 10.1517/17425247.2014.908181 [doi]
PST - ppublish
SO  - Expert Opin Drug Deliv. 2014 Jun;11(6):917-30. doi: 10.1517/17425247.2014.908181. 
      Epub 2014 Apr 19.