PMID- 24746690
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20191210
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 468
IP  - 1-2
DP  - 2014 Jul 1
TI  - Evaluation of P(L)LA-PEG-P(L)LA as processing aid for biodegradable particles 
      from gas saturated solutions (PGSS) process.
PG  - 250-7
LID - S0378-5173(14)00259-2 [pii]
LID - 10.1016/j.ijpharm.2014.04.031 [doi]
AB  - A series of biodegradable P(L)LA-PEG1.5 kDa-P(L)LA copolymers have been 
      synthesized and compared as processing aid versus Poloxamer 407 (PEO-PPO-PEO), in 
      the formulation of protein encapsulated microparticles, using supercritical 
      carbon dioxide (scCO2). Bovine serum albumin (BSA) loaded microcarriers were 
      prepared applying the particles from the gas saturated solutions (PGSS) technique 
      using scCO2 and thus, avoiding the standard practice of organic solvent 
      encapsulation. Four triblock copolymers were synthesized and characterized, 
      particularly in terms of thermal properties and behaviour when exposed to scCO2. 
      The effects of the inclusion of these copolymers in the formulation of 
      poly(alpha-hydroxy acids) based microparticles - e.g. poly(D,L-lactic-co-glycolic 
      acid) (PLGA) and poly(D,L-lactide) (PLA) - were analysed in terms of yield, 
      particle size, morphology and drug release. The use of P(L)LA-PEG1.5 kDa-P(L)LA 
      triblock copolymers were found to increase the yield of the PGSS-based process 
      and to decrease the size of the microparticles produced, in comparison with the 
      formulation containing the Poloxamer 407. Moreover the microparticles formulated 
      with the triblock copolymers possessing the higher hydrophobic character were 
      able to maintain a controlled drug release profile.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Perinelli, D R
AU  - Perinelli DR
AD  - School of Pharmacy, University of Camerino, Via Sant'Agostino 1, Camerino, MC 
      62032, Italy.
FAU - Bonacucina, G
AU  - Bonacucina G
AD  - School of Pharmacy, University of Camerino, Via Sant'Agostino 1, Camerino, MC 
      62032, Italy.
FAU - Cespi, M
AU  - Cespi M
AD  - School of Pharmacy, University of Camerino, Via Sant'Agostino 1, Camerino, MC 
      62032, Italy.
FAU - Naylor, A
AU  - Naylor A
AD  - Critical Pharmaceuticals Limited BioCity, Pennyfoot Street, Nottingham NG1 1GF, 
      United Kingdom.
FAU - Whitaker, M
AU  - Whitaker M
AD  - Critical Pharmaceuticals Limited BioCity, Pennyfoot Street, Nottingham NG1 1GF, 
      United Kingdom.
FAU - Palmieri, G F
AU  - Palmieri GF
AD  - School of Pharmacy, University of Camerino, Via Sant'Agostino 1, Camerino, MC 
      62032, Italy.
FAU - Giorgioni, G
AU  - Giorgioni G
AD  - School of Pharmacy, University of Camerino, Via Sant'Agostino 1, Camerino, MC 
      62032, Italy.
FAU - Casettari, L
AU  - Casettari L
AD  - Department of Biomolecular Sciences, University of Urbino, Piazza Rinascimento 6, 
      Urbino, PU 61029, Italy. Electronic address: luca.casettari@uniurb.it.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20140418
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 0 (Gases)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 106392-12-5 (Poloxamer)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Carbon Dioxide
MH  - Chemistry, Pharmaceutical
MH  - *Chromatography, Supercritical Fluid
MH  - Delayed-Action Preparations
MH  - *Drug Carriers
MH  - Gases
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Kinetics
MH  - Lactic Acid/*chemical synthesis
MH  - Poloxamer/chemical synthesis
MH  - Polyesters
MH  - Polyethylene Glycols/*chemical synthesis
MH  - Polyglycolic Acid/chemical synthesis
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemical synthesis
MH  - Porosity
MH  - Serum Albumin, Bovine/*chemistry
MH  - Solubility
MH  - Technology, Pharmaceutical/*methods
MH  - Viscosity
OTO - NOTNLM
OT  - BSA
OT  - Biodegradable microparticles
OT  - Block copolymers
OT  - PGSS
OT  - scCO(2)
EDAT- 2014/04/22 06:00
MHDA- 2015/01/16 06:00
CRDT- 2014/04/22 06:00
PHST- 2014/02/07 00:00 [received]
PHST- 2014/04/10 00:00 [revised]
PHST- 2014/04/14 00:00 [accepted]
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
AID - S0378-5173(14)00259-2 [pii]
AID - 10.1016/j.ijpharm.2014.04.031 [doi]
PST - ppublish
SO  - Int J Pharm. 2014 Jul 1;468(1-2):250-7. doi: 10.1016/j.ijpharm.2014.04.031. Epub 
      2014 Apr 18.